› 9ija

Electron Microscopy
3.05Å resolution

A local Cryo-EM structure of Bitter taste receptor TAS2R14 with Gi complex

Released:
DOI: 10.2210/pdb9ija/pdb
PDB entry 9ija coloured by chain, front view.
PDB entry 9ija coloured by chain, side view.
PDB entry 9ija coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist.
Tao L, Wang D, Yuan Q, Zhao F, Zhang Y, Du T, Shen S, Xu HE, Li Y, Yang D, Duan J
Cell Res (2024)
PMID: 38969802
Related structures: EMD-60627

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-280344 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Taste receptor type 2 member 14 Chain: R
Molecule details ›
Chain: R
Length: 317 amino acids
Theoretical weight: 36.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NYV8 (Residues: 1-317; Coverage: 100%)
Gene name: TAS2R14
Sequence domains: Taste receptor protein (TAS2R)

Ligands and Environments

2 bound ligands:
Ligand A1AEI 1 x A1AEI
Ligand CLR 1 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.05Å
Relevant EMDB volumes: EMD-60627
Expression system: Spodoptera frugiperda

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