› 9inx

X-ray diffraction
1.72Å resolution

Crystal structure of DAPK1 in complex with compound 10

Released:
DOI: 10.2210/pdb9inx/pdb
PDB entry 9inx coloured by chain, front view.
PDB entry 9inx coloured by chain, side view.
PDB entry 9inx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor.
Yokoyama T, Hisatomi K, Oshima S, Tanaka I, Okada T, Toyooka N
Eur J Med Chem 279 116836 (2024)
PMID: 39243455

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-547134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Death-associated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 33.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53355 (Residues: 1-285; Coverage: 20%)
Gene names: DAPK, DAPK1
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand A1L2W 1 x A1L2W
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 46.603Å b: 62.266Å c: 88.397Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.211
Expression system: Escherichia coli

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