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Cryo-EM structure of Nipah virus L-P (H1165Y) polymerase complex

Electron Microscopy
3.01Å resolution
PDB entry 9ir4 coloured by chain, front view.
PDB entry 9ir4 coloured by chain, side view.
PDB entry 9ir4 coloured by chain, top view.
Source organism: Henipavirus nipahense
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: RNA-directed RNA polymerase L and Phosphoprotein
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Multimeric state: hetero hexamer
Accessible surface area: 69875.22 Å2
Buried surface area: 14163.1 Å2
Dissociation area: 1,296.35 Å2
Dissociation energy (ΔGdiss): 3.2 kcal/mol
Dissociation entropy (TΔSdiss): 11.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-282583

Macromolecules

RNA-directed RNA polymerase L
Chain: A
Length: 2244 amino acids
Theoretical weight: 257.59 KDa
Source organism: Henipavirus nipahense
Expression system: Spodoptera
UniProt:
  • Canonical: Q997F0 (Residues: 1-2244; Coverage: 100%)
Gene name: L
Pfam:
RNA-directed RNA polymerase L in PDB entry 9ir4, assembly 1, front view.
RNA-directed RNA polymerase L in PDB entry 9ir4, assembly 1, side view.
RNA-directed RNA polymerase L in PDB entry 9ir4, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q997F0  
122442004006008001,0001,2001,4001,6001,8002,0002,200
 
10002000
UniProt
Q997F0
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
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Phosphoprotein
Chains: C, D, E, F, G
Length: 709 amino acids
Theoretical weight: 78.39 KDa
Source organism: Henipavirus nipahense
Expression system: Spodoptera
UniProt:
  • Canonical: Q9IK91 (Residues: 1-709; Coverage: 100%)
Gene name: P/V/C
Pfam:
Phosphoprotein in PDB entry 9ir4, assembly 1, front view.
Phosphoprotein in PDB entry 9ir4, assembly 1, side view.
Phosphoprotein in PDB entry 9ir4, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9IK91  
1709100200300400500600700
 
200400600
UniProt
Q9IK91
Chains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Molecule details ›

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