9ite

Electron Microscopy
3.06Å resolution

LPA-bound LPAR6 in complex with miniG13

Released:
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6.
Proc Natl Acad Sci U S A 122 e2415426122 (2025)
PMID: 39847322
Related structures: EMD-60859

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-283922 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
engineered miniGa13 Chain: A
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 26.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 345 amino acids
Theoretical weight: 37.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
scFv16 Chain: E
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Lysophosphatidic acid receptor 6 Chain: R

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.06Å
Relevant EMDB volumes: EMD-60859
Expression system: Spodoptera frugiperda