9izv

Electron Microscopy
3.02Å resolution

Cryo-EM structure of ALDH6A1-Y172H & R535C

Released:

Function and Biology Details

Reaction catalysed:
2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) = propanoyl-CoA + HCO(3)(-) + NADH

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
PDBe Complex ID:
PDB-CPX-274417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 509 amino acids
Theoretical weight: 55.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q02252 (Residues: 33-535; Coverage: 94%)
Gene names: ALDH6A1, MMSDH
Sequence domains: Aldehyde dehydrogenase family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.02Å
Relevant EMDB volumes: EMD-61043
Expression system: Escherichia coli BL21(DE3)