Function and Biology Details
Reactions catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-291669 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
Elongin-B
Molecule details ›
Chains: D, H
Length: 121 amino acids
Theoretical weight: 13.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 121 amino acids
Theoretical weight: 13.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q15370 (Residues: 1-118; Coverage: 100%)
Sequence domains: Ubiquitin family
Cullin-2
Molecule details ›
Chains: A, B
Length: 750 amino acids
Theoretical weight: 87.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 750 amino acids
Theoretical weight: 87.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q13617 (Residues: 2-745; Coverage: 98%)
Sequence domains:
Elongin-C
Protein fem-1 homolog B
E3 ubiquitin-protein ligase RBX1, N-terminally processed
