› 9jd6

Electron Microscopy
3.06Å resolution

Cryo-EM structure of human TauT in presence of Piperidine-4-sulfonate, determined in an inward-facing occluded conformation

Released:
DOI: 10.2210/pdb9jd6/pdb
PDB entry 9jd6 coloured by chain, front view.
PDB entry 9jd6 coloured by chain, side view.
PDB entry 9jd6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transport and inhibition mechanism for human TauT-mediated taurine uptake.
Chao Y, Zhou Z, Xia H, Yang C, Li T, Tang YQ, Shu Y, Ba Q, Hong J, Li D, Qu Q
Cell Res (2025)
PMID: 39837997
Related structures: EMD-61382

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-286579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium- and chloride-dependent taurine transporter Chain: A
Molecule details ›
Chain: A
Length: 606 amino acids
Theoretical weight: 68.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31641 (Residues: 1-582; Coverage: 94%)
Gene name: SLC6A6
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

5 bound ligands:
Ligand NAG 3 x NAG
Ligand CL 1 x CL
Ligand Y01 2 x Y01
Ligand NA 1 x NA
Ligand A1EBD 1 x A1EBD
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.06Å
Relevant EMDB volumes: EMD-61382
Expression system: Homo sapiens

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