› 9kqe

Electron Microscopy
3Å resolution

Cryo-EM structure of human VMAT2 in complex with dopamine.

Released:
DOI: 10.2210/pdb9kqe/pdb
PDB entry 9kqe coloured by chain, front view.
PDB entry 9kqe coloured by chain, side view.
PDB entry 9kqe coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Drug inhibition and substrate transport mechanisms of human VMAT2.
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun 16 323 (2025)
PMID: 39747030
Related structures: EMD-62501

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233030 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptic vesicular amine transporter Chain: A
Molecule details ›
Chain: A
Length: 632 amino acids
Theoretical weight: 69.13 KDa
Source organism: Escherichia coli
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05940 (Residues: 12-514; Coverage: 98%)
Gene names: SLC18A2, SVMT, VMAT2
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

1 bound ligand:
Ligand LDP 1 x LDP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3Å
Relevant EMDB volumes: EMD-62501
Expression system: Homo sapiens

Quick links