9kqe

Electron Microscopy
3Å resolution

Cryo-EM structure of human VMAT2 in complex with dopamine.

Released:
Source organisms:
Primary publication:
Drug inhibition and substrate transport mechanisms of human VMAT2.
Nat Commun 16 323 (2025)
PMID: 39747030
Related structures: EMD-62501

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-283882 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble cytochrome b562; Synaptic vesicular amine transporter Chain: A
Molecule details ›
Chain: A
Length: 632 amino acids
Theoretical weight: 69.13 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: Q05940 (Residues: 12-514; Coverage: 98%)
Gene names: SLC18A2, SVMT, VMAT2, cybC
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-62501
Expression system: Homo sapiens