› 9l2f

Electron Microscopy
3.55Å resolution

Structure of SARM1 bound to M1 and 1AD in the active state

Released:
DOI: 10.2210/pdb9l2f/pdb
PDB entry 9l2f coloured by chain, front view.
PDB entry 9l2f coloured by chain, side view.
PDB entry 9l2f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Huang Y, Zhang J, Zheng S, Wang X
Related structures: EMD-62774

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD(+) hydrolase SARM1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 732 amino acids
Theoretical weight: 80.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6SZW1 (Residues: 1-724; Coverage: 100%)
Gene names: KIAA0524, SAMD2, SARM, SARM1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand A1EIV 8 x A1EIV
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.55Å
Relevant EMDB volumes: EMD-62774
Expression system: Homo sapiens

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