› 9l49

X-ray diffraction
3Å resolution

Crystal structure of HLA-C*12:03-RV9

Released:
DOI: 10.2210/pdb9l49/pdb
Model geometry
Fit model/data
PDB entry 9l49 coloured by chain, front view.
PDB entry 9l49 coloured by chain, side view.
PDB entry 9l49 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biochemical and structural insights into position 97 micropolymorphisms in human leukocyte antigen (HLA)-C*12 allotypes and their differential disease associations.
Yang M, Zhong P, Liu Q, Jiao H, Lei J, Wei P
Int J Biol Macromol 306 141681 (2025)
PMID: 40044006

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-290644 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 31.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2UV93 (Residues: 1-273; Coverage: 100%)
Gene name: HLA-C
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Toll-like receptor 9 Chain: C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NFPSS BEAMLINE BL18U
Spacegroup: I222
Unit cell:
a: 85.309Å b: 95.27Å c: 119.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.204 0.235
Expression system: Escherichia coli

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