› 9l4a

X-ray diffraction
1.9Å resolution

Crystal structure of HLA-C*12:02-MY9

Released:
DOI: 10.2210/pdb9l4a/pdb
Model geometry
Fit model/data
PDB entry 9l4a coloured by chain, front view.
PDB entry 9l4a coloured by chain, side view.
PDB entry 9l4a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biochemical and structural insights into position 97 micropolymorphisms in human leukocyte antigen (HLA)-C*12 allotypes and their differential disease associations.
Yang M, Zhong P, Liu Q, Jiao H, Lei J, Wei P
Int J Biol Macromol 306 141681 (2025)
PMID: 40044006

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-290643 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 273 amino acids
Theoretical weight: 31.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: S5DHS4 (Residues: 1-273; Coverage: 100%)
Gene name: HLA-C
Sequence domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 99 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
MY9 Chains: C, F

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17UM
Spacegroup: P212121
Unit cell:
a: 79.52Å b: 96.4Å c: 121.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.164 0.207
Expression system: Escherichia coli

Quick links