Entry status  (1)

REL

(48)

Experimental methods  (1)

X-ray diffraction

(48)

Authors  (144)

Jaskolski M

(8)

Anderson WF

(7)

Center for Structural Genomics of Infectious Diseases (CSGID)

(7)

Dubrovska I

(7)

Komoto J

(7)

Kwon K

(7)

Minasov G

(7)

Ogawa H

(7)

Shuvalova L

(7)

Takata Y

(7)

Takusagawa F

(7)

Bishop B

(6)

Fujioka M

(6)

Gomi T

(6)

Kiryukhina O

(6)

Gokulan K

(5)

Huang Y

(5)

Ioerger TR

(5)

Kuppan G

(5)

Kusakabe Y

(5)

Manszewski T

(5)

Owen JL

(5)

Reddy MC

(5)

Reddy MCM

(5)

Sacchettini JC

(5)

Shetty ND

(5)

Tanaka N

(5)

Arrowsmith CH

(4)

Berglund H

(4)

Bountra C

(4)

Collins R

(4)

Edwards AM

(4)

Flodin S

(4)

Flores A

(4)

Graslund S

(4)

Hammarstrom M

(4)

Ishihara M

(4)

Johansson I

(4)

Karlberg T

(4)

Kotenyova T

(4)

Moche M

(4)

Nordlund P

(4)

Nyman T

(4)

Persson C

(4)

Schutz P

(4)

Seattle Structural Genomics Center for Infectious Disease (SSGCID)

(4)

Siponen MI

(4)

Szpotkowski K

(4)

Thorsell AG

(4)

Tresaugues L

(4)

Weigelt J

(4)

Welin M

(4)

Wisniewska M

(4)

Yamada T

(4)

Brzezinski K

(3)

Dauter Z

(3)

Johansson A

(3)

Sagemark J

(3)

Schueler H

(3)

Structural Genomics Consortium (SGC)

(3)

Van Den Berg S

(3)

Borchardt RT

(2)

Chen CC

(2)

Chen Z

(2)

Cole PA

(2)

Guo RT

(2)

Howell PL

(2)

Hu Y

(2)

Huang CH

(2)

Karukurichi KR

(2)

Kavran JM

(2)

Ko TP

(2)

Leahy DJ

(2)

Lehtio L

(2)

Qian G

(2)

Shao W

(2)

Turner MA

(2)

Wang Y

(2)

Xiao X

(2)

Yang Y

(2)

Zheng Y

(2)

Abendroth J

(1)

Akiko K

(1)

Choi S

(1)

Choi WJ

(1)

Dahlgren LG

(1)

Dranow DM

(1)

Edwards TE

(1)

Gardberg A

(1)

Halavaty A

(1)

Heo YS

(1)

Hershfield MS

(1)

Hua DH

(1)

Hwang KY

(1)

Imiolczyk B

(1)

Ito Y

(1)

Iwasaki H

(1)

Jeong LS

(1)

Kashima A

(1)

Kim HO

(1)

 

More...

Homo / hetero assembly  (2)

homo

(47)

hetero

(1)

Assembly composition  (2)

protein structure

(47)

protein/protein complex

(1)

Assembly polymer count  (3)

tetramer

(43)

dimer

(4)

monomer

(1)

Resolution distribution

1.0 - 1.5

(2)

1.5 - 2

(15)

2.0 - 2.5

(16)

2.5 - 3

(15)

Release year distribution

1995 - 2000

(2)

2000 - 2005

(7)

2005 - 2010

(14)

2010 - 2015

(12)

2015 - 2020

(19)

Journal  (13)

To be published

(19)

J Biol Chem

(6)

Protein Sci

(5)

Acta Crystallogr D Biol Crystallogr

(4)

IUCrJ

(4)

Biochemistry

(2)

J Struct Biol

(2)

Biochem Pharmacol

(1)

Bioorg Med Chem

(1)

Int J Biochem Cell Biol

(1)

J Med Chem

(1)

J Mol Biol

(1)

Nat Struct Biol

(1)

Organism superkingdom  (2)

Eukaryota

(33)

Bacteria

(15)

Organism name  (16)

Homo sapiens

(8)

Rattus norvegicus

(7)

Bradyrhizobium elkanii

(5)

Cryptosporidium parvum Iowa II

(5)

Mus musculus

(4)

Mycobacterium tuberculosis H37Rv

(4)

Lupinus luteus

(3)

Burkholderia pseudomallei 1710b

(2)

Cryptosporidium parvum

(2)

Thermotoga maritima MSB8

(2)

Brucella abortus 2308

(1)

Leishmania major

(1)

Mycobacterium tuberculosis

(1)

Naegleria fowleri

(1)

Plasmodium falciparum 3D7

(1)

Trypanosoma brucei

(1)

Molecule name  (26)

Adenosylhomocysteinase

(46)

S-adenosyl-L-homocysteine hydrolase

(36)

AdoHcyase

(31)

S-adenosylhomocysteinase

(7)

BeSAHase

(5)

SAHase

(5)

CUBP

(4)

Liver copper-binding protein

(4)

Adenosylhomocysteinase 3

(1)

AdoHcyase 2

(1)

AdoHcyase 3

(1)

DC-expressed AHCY-like molecule

(1)

IP(3)Rs binding protein released with IP(3)

(1)

IP(3)Rs binding protein released with IP(3) 2

(1)

IRBIT

(1)

IRBIT2

(1)

Long-IRBIT

(1)

PfSAHH

(1)

Putative adenosylhomocysteinase 2

(1)

S-adenosyl-L-homocysteine hydrolase 2

(1)

S-adenosyl-L-homocysteine hydrolase 3

(1)

S-adenosyl-l-homocysteine Hydrolase

(1)

S-adenosylhomocysteine hydrolase

(1)

S-adenosylhomocysteine hydrolase, putative

(1)

S-adenosylhomocysteine hydrolase-like protein 1

(1)

S-adenosylhomocysteine hydrolase-like protein 2

(1)

Molecule type  (1)

Protein

(48)

Gene names  (22)

ahcY

(15)

Ahcy

(11)

SAHH

(9)

cgd3_80

(7)

AHCY

(6)

MTCY20B11.23c

(5)

Rv3248c

(5)

sahH

(5)

SHH

(3)

BURPS1710b_0057

(2)

TM_0172

(2)

AHCYL1

(1)

AHCYL2

(1)

BAB1_2099

(1)

DCAL

(1)

IRBIT

(1)

KIAA0828

(1)

LMJF_36_3910

(1)

NF0035640

(1)

PFE1050w

(1)

Tb11.01.1350

(1)

XPVKONA

(1)

Interacting Molecules  (1)

Adenosylhomocysteinase

(1)

Interacting ligands  (42)

NAD : NICOTINAMIDE-ADENINE-DINUCLEOTIDE

(44)

ADN : ADENOSINE

(17)

NA : SODIUM ION

(12)

GOL : GLYCEROL

(7)

PEG : DI(HYDROXYETHYL)ETHER

(7)

TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL

(6)

ADE : ADENINE

(4)

CL : CHLORIDE ION

(4)

NAI : 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE

(4)

P6G : HEXAETHYLENE GLYCOL

(4)

ACT : ACETATE ION

(3)

EDO : 1,2-ETHANEDIOL

(3)

PO4 : PHOSPHATE ION

(3)

SO4 : SULFATE ION

(3)

3AD : 3'-DEOXYADENOSINE

(2)

ARJ : (2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-2-hydroxy-5-(hydroxymethyl)cyclopentanone

(2)

DEA : D-ERITADENINE

(2)

2FA : 2-(6-AMINO-2-FLUORO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL

(1)

3D1 : (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol

(1)

3DD : (2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-2,3-DIHYDROXYBUTANOIC ACID

(1)

3DH : 5'-S-ethyl-5'-thioadenosine

(1)

6OS : Neplanocin-A

(1)

7CY : (1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol

(1)

AD3 : 3-DEAZA-ADENOSINE

(1)

ADC : (1'R,2'S)-9-(2-HYDROXY-3'-KETO-CYCLOPENTEN-1-YL)ADENINE

(1)

ADY : 3'-OXO-ADENOSINE

(1)

AFX : (4S,5S)-4-(6-amino-9H-purin-9-yl)-3-fluoro-5-hydroxy-2-(hydroxymethyl)cyclopent-2-en-1-one

(1)

BR : BROMIDE ION

(1)

IPA : ISOPROPYL ALCOHOL

(1)

K : POTASSIUM ION

(1)

NH4 : AMMONIUM ION

(1)

NO3 : NITRATE ION

(1)

NOC : 3-(6-AMINO-PURIN-9-YL)-5-HYDROXYMETHYL-CYCLOPENTANE-1,2-DIOL

(1)

NRN : (1S,2R,3S,4R)-4-(6-aminopurin-9-yl)cyclopentane-1,2,3-triol

(1)

P33 : 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL

(1)

PG4 : TETRAETHYLENE GLYCOL

(1)

PGE : TRIETHYLENE GLYCOL

(1)

RAB : 2-(6-AMINO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL

(1)

RBV : 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide

(1)

SAH : S-ADENOSYL-L-HOMOCYSTEINE

(1)

XFA : 2-{[5-chloro-2-(4-chlorophenoxy)phenyl](2-{[2-(methylamino)ethyl]amino}-2-oxoethyl)amino}-N-(1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide

(1)

ZD2 : (2S)-4-(6-amino-9H-purin-9-yl)-2-hydroxybutanoic acid

(1)

EC number / name  (1)

3.3.1.1 : Adenosylhomocysteinase

(1)

Biological function  (11)

adenosylhomocysteinase activity

(46)

hydrolase activity

(46)

protein binding

(15)

NAD binding

(11)

copper ion binding

(11)

identical protein binding

(11)

nucleotide binding

(10)

adenosylselenohomocysteinase activity

(7)

adenyl nucleotide binding

(7)

NAD+ binding

(5)

zymogen binding

(5)

Biological process  (13)

one-carbon metabolic process

(46)

S-adenosylmethionine cycle

(42)

L-homocysteine biosynthetic process

(15)

S-adenosylhomocysteine catabolic process

(7)

chronic inflammatory response to antigenic stimulus

(7)

circadian sleep/wake cycle

(7)

response to hypoxia

(7)

response to nutrient

(7)

adenosine metabolic process

(5)

adhesion of symbiont to host cell

(5)

entry of bacterium into host cell

(5)

methionine catabolic process

(5)

S-methylmethionine cycle

(4)

Biological cell component  (9)

cytosol

(46)

cytoplasm

(34)

endoplasmic reticulum

(17)

melanosome

(17)

nucleus

(17)

extracellular exosome

(6)

extracellular region

(5)

peptidoglycan-based cell wall

(5)

plasma membrane

(5)

Compound cofactor class  (1)

Nicotinamide-adenine dinucleotide

(1)

SCOP fold  (2)

Flavodoxin-like

(10)

NAD(P)-binding Rossmann-fold domains

(10)

SCOP family  (2)

Formate/glycerate dehydrogenases, NAD-domain

(10)

S-adenosylhomocystein hydrolase

(10)

CATH class  (1)

Alpha Beta

(48)

CATH topology  (1)

Rossmann fold

(48)

Pfam accession / name  (2)

PF00670 : AdoHcyase_NAD

(48)

PF05221 : AdoHcyase

(48)

Diffraction protocol  (1)

Single wavelength

(47)

Diffraction radiation source type  (2)

Synchrotron

(41)

Rotating anode

(7)

Diffraction source  (25)

RIGAKU RU200

(6)

APS BEAMLINE 19-ID

(5)

APS BEAMLINE 21-ID-G

(5)

APS BEAMLINE 21-ID-F

(3)

BESSY BEAMLINE 14.2

(3)

PHOTON FACTORY BEAMLINE AR-NE3A

(3)

EMBL/DESY, HAMBURG BEAMLINE X13

(2)

NSRRC BEAMLINE BL13C1

(2)

PHOTON FACTORY BEAMLINE AR-NW12A

(2)

SSRL BEAMLINE BL7-1

(2)

ALS BEAMLINE 5.0.1

(1)

APS BEAMLINE 19-BM

(1)

APS BEAMLINE 23-ID-D

(1)

BESSY BEAMLINE 14.1

(1)

DIAMOND BEAMLINE I02

(1)

DIAMOND BEAMLINE I03

(1)

EMBL/DESY, HAMBURG BEAMLINE X12

(1)

ESRF BEAMLINE ID23-1

(1)

NSLS BEAMLINE X12C

(1)

NSLS BEAMLINE X8C

(1)

PAL/PLS BEAMLINE 6B

(1)

PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)

(1)

PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)

(1)

RIGAKU MICROMAX-007 HF

(1)

SPRING-8 BEAMLINE BL24XU

(1)

Synchrotron site  (13)

APS

(15)

Photon Factory

(5)

BESSY

(4)

EMBL/DESY, Hamburg

(3)

Diamond

(2)

NSLS

(2)

NSRRC

(2)

PETRA III, EMBL c/o DESY

(2)

SSRL

(2)

ALS

(1)

ESRF

(1)

PAL/PLS

(1)

SPring-8

(1)

Diffraction detector type  (3)

CCD

(38)

Image plate

(9)

Pixel

(1)

Refinement software  (6)

REFMAC

(25)

PHENIX

(8)

CNS

(7)

X-PLOR

(6)

BUSTER

(1)

CNX

(1)

Representative Structures

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