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Entry Information
Entry status
(1)
Experimental methods
(2)
X-ray diffraction
(22)
Solution NMR
(3)
Authors
(121)
TB Structural Genomics Consortium (TBSGC)
(6)
Cascio D
(5)
Chan S
(5)
Eisenberg D
(5)
Integrated Center for Structure and Function Innovation (ISFI)
(5)
Ahn CJ
(4)
Arbing MA
(4)
Harris L
(4)
He Q
(4)
Holton T
(4)
Kuo E
(4)
Lu J
(4)
Menchavez PT
(4)
Nguyen L
(4)
Sawaya MR
(4)
Shin A
(4)
Zhou TT
(4)
Holton SJ
(3)
Hunter WN
(3)
Panjikar S
(3)
Poulsen C
(3)
Song YH
(3)
Wilmanns M
(3)
Ahn C
(2)
Carr MD
(2)
Chao JA
(2)
Chapados BR
(2)
Debler EW
(2)
Fyfe PK
(2)
Gao S
(2)
Gries F
(2)
Kondabagil K
(2)
Lee JH
(2)
Lightbody KL
(2)
Muskett FW
(2)
Rao VB
(2)
Renshaw PS
(2)
Rossmann MG
(2)
Schneemann A
(2)
Sun S
(2)
Sundaramoorthy R
(2)
Veverka V
(2)
Williamson JR
(2)
Xiang Y
(2)
Anthony M
(1)
Arbing M
(1)
Avilov SV
(1)
Bendebury A
(1)
Bernhards RC
(1)
Burke B
(1)
Carr M
(1)
Chen JC
(1)
Cheng Y
(1)
Connolly L
(1)
Cox JS
(1)
Dordor A
(1)
Dovala D
(1)
Dovala DL
(1)
Finer-Moore J
(1)
Frenkiel TA
(1)
Gordon SV
(1)
Gottlinger H
(1)
Gu J
(1)
Göttlinger H
(1)
Hartlieb B
(1)
Hewinson RG
(1)
Holton J
(1)
Honke K
(1)
Hughson FM
(1)
Ihara H
(1)
Ikeda Y
(1)
Ilghari D
(1)
Izaurralde E
(1)
Jeffrey PD
(1)
Jing X
(1)
Kaufmann M
(1)
Kelly G
(1)
Kirsty LL
(1)
Korber S
(1)
Körber S
(1)
Li X
(1)
Lingel A
(1)
Lupashin VV
(1)
Martinelli N
(1)
Matsumoto A
(1)
Miguet N
(1)
Miyoshi E
(1)
Nakagawa A
(1)
Nakamura A
(1)
Ng WM
(1)
Norman J
(1)
Pallen M
(1)
Palmer T
(1)
Phan T
(1)
Philip RS
(1)
Ribeiro EA
(1)
Richardson BC
(1)
Robinson H
(1)
Rosenberg OS
(1)
Sabin C
(1)
More...
Homo / hetero assembly
(2)
homo
(14)
hetero
(11)
Assembly composition
(3)
protein structure
(14)
protein/protein complex
(9)
RNA/protein complex
(2)
Assembly polymer count
(6)
dimer
(17)
tetramer
(4)
dodecamer
(1)
monomer
(1)
trimer
(1)
undecamer
(1)
Resolution distribution
1.0 - 1.5
(2)
1.5 - 2
(9)
2.0 - 2.5
(3)
2.5 - 3
(8)
Release year distribution
2000 - 2005
(4)
2005 - 2010
(17)
2010 - 2015
(14)
2015 - 2020
(1)
Journal
(13)
PLoS One
(7)
J Mol Biol
(3)
Proc Natl Acad Sci U S A
(3)
Nat Struct Mol Biol
(2)
To be published
(2)
Acta Crystallogr Sect F Struct Biol Cryst Commun
(1)
Biochemistry
(1)
Cell
(1)
EMBO J
(1)
EMBO Rep
(1)
Glycobiology
(1)
J. Biol. Chem.
(1)
Protein Sci
(1)
Macromolecules
Organism superkingdom
(3)
Bacteria
(16)
Viruses
(6)
Eukaryota
(3)
Organism name
(15)
Mycobacterium tuberculosis H37Rv
(4)
Flock House virus
(3)
Homo sapiens
(3)
Aeromonas virus 44RR2
(2)
Mycobacterium tuberculosis
(2)
Staphylococcus aureus
(2)
Streptococcus agalactiae 2603V/R
(2)
Geobacillus thermodenitrificans
(1)
Mycobacterium tuberculosis variant bovis
(1)
Mycobacteroides abscessus ATCC 19977
(1)
Mycolicibacterium smegmatis MC2 155
(1)
Nodamura virus
(1)
Pseudomonas aeruginosa UCBPP-PA14
(1)
Streptococcus agalactiae NEM316
(1)
Thermomonospora curvata DSM 43183
(1)
Molecule name
(44)
ESAT-6-like protein
(4)
Protein B2
(4)
Uncharacterized protein
(4)
10 kDa culture filtrate antigen CFP-10
(2)
6 kDa early secretory antigenic target
(2)
ESAT-6
(2)
ESAT-6-like protein EsxB
(2)
ESAT-6-like protein EsxG
(2)
ESAT-6-like protein EsxH
(2)
ESAT-6-like protein EsxO
(2)
ESAT-6-like protein EsxP
(2)
ESAT-6-like protein SAG1039
(2)
Ess extracellular protein A
(2)
Secreted antigenic protein MTSA-10
(2)
Terminase DNA packaging enzyme small subunit
(2)
Type VII secretion system extracellular protein A
(2)
10 kDa antigen CFP7
(1)
Alpha-(1,6)-fucosyltransferase
(1)
Alpha1-6FucT
(1)
CFP-10
(1)
CFP-7
(1)
CHMP4b
(1)
COG complex subunit 4
(1)
Charged multivesicular body protein 4b
(1)
Chromatin-modifying protein 4b
(1)
Component of oligomeric Golgi complex 4
(1)
Conserved oligomeric Golgi complex subunit 4
(1)
Conserved protein TB9.8
(1)
ESAT-6-like protein EsxA
(1)
ESAT-6-like protein EsxR
(1)
ExsD
(1)
Fucosyltransferase 8
(1)
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
(1)
GDP-fucose--glycoprotein fucosyltransferase
(1)
Glycoprotein 6-alpha-L-fucosyltransferase
(1)
Low molecular weight protein antigen 7
(1)
Protein TB10.4
(1)
SNF7 homolog associated with Alix 1
(1)
SNF7-2
(1)
TB10.3
(1)
Vacuolar protein sorting-associated protein 32-2
(1)
Vps32-2
(1)
hSnf7-2
(1)
hVps32-2
(1)
Molecule type
(1)
Protein
(25)
Gene names
(47)
16
(2)
esxA
(5)
B2
(4)
esxB
(3)
MTCY98.15c
(2)
MTCY98.16c
(2)
MTV027.10
(2)
Rv2346c
(2)
Rv2347c
(2)
Rv3875
(2)
SAG1039
(2)
SAV0282
(2)
cfp10
(2)
esaT6
(2)
esxG
(2)
esxH
(2)
esxO
(2)
esxP
(2)
lhp
(2)
mtsA10
(2)
BQ2027_MB3904
(1)
C20orf178
(1)
CHMP4B
(1)
COG4
(1)
FUT8
(1)
GTNG_0416
(1)
MAB_3112
(1)
MAB_3113
(1)
MSMEG_0620
(1)
MSMEG_0621
(1)
MSMEI_0604
(1)
MSMEI_0605
(1)
MTV012.33c
(1)
MTV027.09
(1)
MTV035.16
(1)
PA14_42380
(1)
Rv0287
(1)
Rv0288
(1)
Rv3019c
(1)
Rv3874
(1)
SHAX1
(1)
Tcur_0610
(1)
Tcur_0611
(1)
cfp7
(1)
esxR
(1)
exsD
(1)
gbs1074
(1)
Interacting Molecules
(10)
5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU)P*CP*CP*AP*(5BU)P*GP*C)-3'
(2)
6 kDa early secretory antigenic target
(2)
ESAT-6-like protein
(2)
ESAT-6-like protein EsxB
(2)
ESAT-6-like protein EsxG
(2)
ESAT-6-like protein EsxH
(2)
ESAT-6-like protein EsxO
(2)
ESAT-6-like protein EsxP
(2)
ESAT-6-like protein EsxA
(1)
ESAT-6-like protein EsxS
(1)
Interacting ligands
(8)
GOL : GLYCEROL
(3)
SO4 : SULFATE ION
(3)
ZN : ZINC ION
(3)
ACT : ACETATE ION
(2)
BME : BETA-MERCAPTOETHANOL
(1)
CAC : CACODYLATE ION
(1)
IMD : IMIDAZOLE
(1)
PO4 : PHOSPHATE ION
(1)
Function and Biology
EC number / name
(1)
2.4.1.68 : Glycoprotein 6-alpha-L-fucosyltransferase
(1)
Biological function
(5)
protein binding
(4)
host cell surface binding
(2)
protein homodimerization activity
(2)
glycoprotein 6-alpha-L-fucosyltransferase activity
(1)
metal ion binding
(1)
Biological process
(5)
protein secretion by the type VII secretion system
(2)
symbiont-mediated perturbation of host signal transduction pathway
(2)
symbiont-mediated suppression of host T-cell mediated immune response
(2)
protein glycosylation
(1)
vacuolar transport
(1)
Biological cell component
(14)
extracellular region
(10)
peptidoglycan-based cell wall
(4)
plasma membrane
(4)
cytosol
(3)
membrane
(3)
cytoplasm
(2)
host cell cytoplasm
(2)
host cell endoplasmic reticulum
(2)
host cell membrane
(2)
host cell plasma membrane
(2)
host cell surface
(2)
Golgi cisterna membrane
(1)
phagocytic vesicle lumen
(1)
protein-containing complex
(1)
Sequence and Structure classification
SCOP fold
(2)
ROP-like
(3)
Ferritin-like
(1)
SCOP family
(2)
FHV B2 protein-like
(3)
ESAT-6 like
(1)
CATH class
(2)
Mainly Alpha
(25)
Mainly Beta
(1)
CATH topology
(5)
Helix Hairpins
(25)
Helicase, Ruva Protein; domain 3
(1)
Methane Monooxygenase Hydroxylase; Chain G, domain 1
(1)
SH3 type barrels.
(1)
Substrate Binding Domain Of Dnak; Chain:A; Domain 2
(1)
Pfam accession / name
(10)
PF06013 : WXG100
(15)
PF11473 : B2
(3)
PF11053 : DNA_Packaging
(2)
PF03357 : Snf7
(1)
PF14604 : SH3_9
(1)
PF16806 : ExsD
(1)
PF19745 : FUT8_N_cat
(1)
PF20662 : COG4_C
(1)
PF20904 : ExsD_M
(1)
PF20905 : ExsD_C
(1)
Experimental Information
Diffraction protocol
(2)
Single wavelength
(21)
MAD
(3)
Diffraction radiation source type
(2)
Synchrotron
(21)
Rotating anode
(1)
Diffraction source
(14)
APS BEAMLINE 24-ID-C
(4)
ESRF BEAMLINE ID29
(3)
APS BEAMLINE 23-ID-B
(2)
NSLS BEAMLINE X29A
(2)
SLS BEAMLINE X06DA
(2)
SSRL BEAMLINE BL11-1
(2)
APS BEAMLINE 24-ID-E
(1)
DIAMOND BEAMLINE I03
(1)
ESRF BEAMLINE BM14
(1)
ESRF BEAMLINE ID14-1
(1)
ESRF BEAMLINE ID14-4
(1)
RIGAKU MICROMAX-007
(1)
SPRING-8 BEAMLINE BL44XU
(1)
SSRL BEAMLINE BL12-2
(1)
Synchrotron site
(7)
APS
(7)
ESRF
(6)
SSRL
(3)
NSLS
(2)
SLS
(2)
Diamond
(1)
SPring-8
(1)
Diffraction detector type
(3)
CCD
(17)
Pixel
(3)
Image plate
(1)
Refinement software
(3)
REFMAC
(10)
PHENIX
(9)
CNS
(3)
NMR
NMR software packages
(11)
CYANA
(2)
ARIA
(1)
CNS
(1)
NMRPipe
(1)
NMRView
(1)
PROCHECK / PROCHECK-NMR
(1)
Sparky
(1)
TALOS
(1)
TopSpin
(1)
XEASY
(1)
XwinNMR
(1)
NMR Field Strength
400.0 - 500
(1)
500.0 - 600
(3)
600.0 - 700
(3)
700.0 - 800
(2)
800.0 - 900
(3)
900.0 - 1000
(1)
Representative Structures
Representative Structures
Entries
Macromolecules
Compounds
Protein families
Entries 1 to 10 of 25
Select all entries on this page
Crystal Structure of CHMP4B hairpin
Martinelli N, Hartlieb B, Usami Y, Sabin C, Dordor A, Ribeiro EA, Gottlinger H, Weissenhorn W
J Mol Biol
(2012)
[PMID: 22406677 ]
Source organism: Homo sapiens
Assembly composition: protein only structure
Assembly name:
Charged multivesicular body protein 4b
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-190596 (Preferred)
search this ID

Crystal structure of the Mycobacterum abscessus EsxEF (Mab_3112-Mab_3113) complex
Arbing MA, Chan S, Lu J, Kuo E, Harris L, Eisenberg D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC)
PLoS One
(2013)
[PMID: 24312350 ]
Source organism: Mycobacteroides abscessus ATCC 19977
Assembly composition: protein/protein complex
Assembly name:
ESAT-6-like protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-109339 (Preferred)
search this ID
Structural analysis of homodimeric staphylococcal aureus virulence factor EsxA
Sundaramoorthy R, Fyfe PK, Hunter WN
J Mol Biol
(2008)
[PMID: 18773907 ]
Source organism: Staphylococcus aureus
Assembly composition: protein only structure
Assembly name:
Type VII secretion system extracellular protein A
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-189404 (Preferred)
search this ID

Crystal Structure of phage 44RR small terminase gp16
Sun S, Xiang Y, Rossmann MG
Proc Natl Acad Sci U S A
(2012)
[PMID: 22207623 ]
Source organism: Aeromonas virus 44RR2
Assembly composition: protein only structure
Assembly name:
Terminase DNA packaging enzyme small subunit
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-180407 (Preferred)
search this ID

Crystal Structure of phage 44RR small terminase gp16
Sun S, Xiang Y, Rossmann MG
Proc Natl Acad Sci U S A
(2012)
[PMID: 22207623 ]
Source organism: Aeromonas virus 44RR2
Assembly composition: protein only structure
Assembly name:
Terminase DNA packaging enzyme small subunit
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-180406 (Preferred)
search this ID

EsxA : EsxB (SeMet) hetero-dimer from Thermomonospora curvata
Dovala DL, Cox JS, Stroud RM, Rosenberg OS
Cell
(2015)
[PMID: 25865481 ]
Source organism: Thermomonospora curvata DSM 43183
Assembly composition: protein/protein complex
Assembly name:
ESAT-6-like protein EsxA and ESAT-6-like protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-112232 (Preferred)
search this ID
Geobacillus thermodenitrificans EsxA crystal form I
Ng WM, Zoltner M, Palmer T, Hunter WN
To be published
Source organism: Geobacillus thermodenitrificans
Assembly composition: protein only structure
Assembly name:
ESAT-6-like protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-107334 (Preferred)
search this ID

Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP (Rv2346c-Rv2347c) complex in space group C2221
Arbing MA, Chan S, He Q, Harris L, Zhou TT, Kuo E, Ahn CJ, Eisenberg D, TB Structural Genomics Consortium (TBSGC), Integrated Center for Structure and Function Innovation (ISFI)
PLoS One
(2013)
[PMID: 24312350 ]
Source organism: Mycobacterium tuberculosis H37Rv
Assembly composition: protein/protein complex
Bound ligands:
SO4
Assembly name:
ESAT-6-like protein EsxO and ESAT-6-like protein EsxP
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-161862 (Preferred)
search this ID
Crystal Structure of GBS1074, an Esat-6 homologue from Group B Streptococcus
White SA, Shukla A, Anthony M
Acta Crystallogr Sect F Struct Biol Cryst Commun
(2010)
[PMID: 21045286 ]
Source organism: Streptococcus agalactiae NEM316
Assembly composition: protein only structure
Assembly name:
ESAT-6-like protein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-184306 (Preferred)
search this ID

Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP complex (Rv2346c-Rv2347c)
Arbing MA, Chan S, Zhou TT, Ahn C, Harris L, Kuo E, Sawaya MR, Cascio D, Eisenberg D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC)
PLoS One
(2013)
[PMID: 24312350 ]
Source organism: Mycobacterium tuberculosis
Assembly composition: protein/protein complex
Assembly name:
ESAT-6-like protein EsxO and ESAT-6-like protein EsxP
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-161862 (Preferred)
search this ID
Entries 1 to 10 of 25