All structure family : Helical scaffold and wing domains of SecA
 
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Entry Information
Entry status  (1)
REL
(13)
 
Experimental methods  (1)
X-ray diffraction
(13)
 
Authors  (50)
Cusack S
(4)
Economou A
(4)
McCarthy AA
(4)
Papadovasilaki M
(4)
Papanikolau Y
(4)
Petratos K
(4)
Ravelli RB
(4)
Rapoport TA
(3)
Arockiasamy A
(2)
Braunstein M
(2)
Clemons Jr WM
(2)
Clemons WM
(2)
Deisenhofer J
(2)
Fak JJ
(2)
Henry L
(2)
Holzenburg A
(2)
Hunt JF
(2)
Jacobs Jr WR
(2)
Jacobs WR
(2)
McNicholas P
(2)
Oliver DB
(2)
Osborne AR
(2)
Ronning DR
(2)
Sacchettini JC
(2)
Savva CG
(2)
Sharma V
(2)
TB Structural Genomics Consortium (TBSGC)
(2)
Weinkauf S
(2)
Franzini-Armstrong C
(1)
Houdusse A
(1)
Ito K
(1)
Kim H
(1)
Kimura Y
(1)
Li W
(1)
Llinas P
(1)
Menetrey J
(1)
Mori H
(1)
Mukherjea M
(1)
Ménétrey J
(1)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(1)
Safer D
(1)
Selvin PR
(1)
Sweeney HL
(1)
Tahirov TH
(1)
Travaglia M
(1)
Tsukazaki T
(1)
Vassylyev DG
(1)
Vassylyeva MN
(1)
Zimmer J
(1)
Zong AB
(1)
 
Homo / hetero assembly  (2)
homo
(12)
hetero
(1)
 
Assembly composition  (2)
protein structure
(12)
protein/protein complex
(1)
 
Assembly polymer count  (3)
dimer
(9)
monomer
(3)
trimer
(1)
 
Resolution distribution
1.5 - 2
(2)
2.0 - 2.5
(3)
2.5 - 3
(7)
3.0 - 3.5
(1)
 
Release year distribution
2000 - 2005
(6)
2005 - 2010
(7)
 
Journal  (4)
J Mol Biol
(6)
Proc Natl Acad Sci U S A
(4)
Science
(2)
Mol Cell
(1)
 
Macromolecules
Organism superkingdom  (2)
Bacteria
(12)
Eukaryota
(1)
 
Organism name  (5)
Bacillus subtilis
(5)
Escherichia coli
(4)
Mycobacterium tuberculosis
(2)
Sus scrofa
(1)
Thermus thermophilus HB8
(1)
 
Molecule name  (5)
Protein translocase subunit SecA
(10)
Protein translocase subunit SecA 1
(2)
tbSecA
(2)
Unconventional myosin-6
(1)
Unconventional myosin-VI
(1)
 
Molecule type  (1)
Protein
(13)
 
Gene names  (13)
secA
(10)
BSU35300
(5)
div+
(5)
JW0096
(4)
azi
(4)
b0098
(4)
pea
(4)
prlD
(4)
MTCY20B11.15c
(2)
Rv3240c
(2)
secA1
(2)
MYO6
(1)
TTHA1251
(1)
 
Interacting Molecules  (1)
Calmodulin
(1)
 
Interacting ligands  (5)
ADP : ADENOSINE-5'-DIPHOSPHATE
(5)
MG : MAGNESIUM ION
(3)
SO4 : SULFATE ION
(2)
ANP : PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
(1)
ATP : ADENOSINE-5'-TRIPHOSPHATE
(1)
 
Function and Biology
EC number / name  (1)
7.4.2.8 : Protein-secreting ATPase
(12)
 
Biological function  (11)
ATP binding
(12)
nucleotide binding
(12)
protein-exporting ATPase activity
(12)
metal ion binding
(9)
protein binding
(6)
identical protein binding
(4)
preprotein binding
(4)
ribonucleoprotein complex binding
(4)
ribosome binding
(4)
zinc ion binding
(4)
ATP hydrolysis activity
(2)
 
Biological process  (9)
intracellular protein transmembrane transport
(12)
intracellular protein transport
(12)
protein import
(12)
protein targeting
(12)
protein transport
(12)
protein transport by the Sec complex
(12)
chaperone-mediated protein folding
(4)
protein secretion
(4)
protein targeting to membrane
(4)
 
Biological cell component  (9)
cell envelope Sec protein transport complex
(12)
cytoplasm
(12)
membrane
(12)
plasma membrane
(12)
membrane raft
(5)
cytoplasmic side of plasma membrane
(4)
cytosol
(3)
extracellular region
(2)
peptidoglycan-based cell wall
(2)
 
Sequence and Structure classification
SCOP fold  (3)
Helical scaffold and wing domains of SecA
(6)
P-loop containing nucleoside triphosphate hydrolases
(6)
Pre-protein crosslinking domain of SecA
(6)
 
SCOP family  (3)
Helical scaffold and wing domains of SecA
(6)
Pre-protein crosslinking domain of SecA
(6)
Tandem AAA-ATPase domain
(6)
 
CATH class  (3)
Alpha Beta
(12)
Mainly Alpha
(12)
Special
(1)
 
CATH topology  (5)
Helical scaffold and wing domains of SecA
(13)
Rossmann fold
(12)
Pre-protein croslinking domain of SecA
(8)
cAMP-dependent Protein Kinase, Chain A
(3)
Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A
(2)
 
Pfam accession / name  (5)
PF01043 : SecA_PP_bind
(12)
PF07516 : SecA_SW
(12)
PF07517 : SecA_DEAD
(12)
PF21090 : P-loop_SecA
(12)
PF02810 : SEC-C
(2)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(13)
MAD
(2)
 
Diffraction radiation source type  (1)
Synchrotron
(13)
 
Diffraction source  (7)
APS BEAMLINE 19-ID
(4)
ESRF BEAMLINE ID14-4
(4)
ESRF BEAMLINE ID2
(2)
NSLS BEAMLINE X25
(2)
APS BEAMLINE 14-BM-D
(1)
ESRF BEAMLINE ID23-1
(1)
SPRING-8 BEAMLINE BL45XU
(1)
 
Synchrotron site  (4)
ESRF
(7)
APS
(4)
NSLS
(2)
SPring-8
(1)
 
Diffraction detector type  (3)
CCD
(8)
Area detector
(2)
Image plate
(1)
 
Refinement software  (4)
REFMAC
(6)
CNS
(4)
X-PLOR
(2)
PHENIX
(1)
 
Representative Structures
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Entries 1 to 10 of 13
Entries 1 to 10 of 13
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Myosin lever arm
Mukherjea M, Llinas P, Kim H, Travaglia M, Safer D, Zong AB, Menetrey J, Franzini-Armstrong C, Selvin PR, Houdusse A, Sweeney HL
Mol Cell (2009) [PMID: 19664948  ]
Assembly composition: protein/protein complex
Bound ligands: CA    MG    CA    MG   
Assembly name: Calmodulin and Unconventional myosin-VI (Preferred)   search this complex
PDBe complex ID: PDB-CPX-158580 (Preferred)   search this ID
PDBe-KB: Q29122    P62152   
X-ray diffraction
2.7Å resolution
Released: 8 Sep 2009
Model geometry
Fit model/data
3gn4
3gn4
3gn4
CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEX WITH ADPBS
Sharma V, Arockiasamy A, Ronning DR, Savva CG, Holzenburg A, Braunstein M, Jacobs Jr WR, Sacchettini JC, TB Structural Genomics Consortium (TBSGC)
Proc Natl Acad Sci U S A (2003) [PMID: 12606717  ]
Assembly composition: protein only structure
Bound ligands: MG    ADP    ADP    MG   
Assembly name: Protein translocase subunit SecA 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161506 (Preferred)   search this ID
PDBe-KB: P9WGP5   
X-ray diffraction
2.601Å resolution
Released: 4 Mar 2003
Model geometry
Fit model/data
Data not deposited
1nkt
1nkt
1nkt
CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM
Sharma V, Arockiasamy A, Ronning DR, Savva CG, Holzenburg A, Braunstein M, Jacobs Jr WR, Sacchettini JC, TB Structural Genomics Consortium (TBSGC)
Proc Natl Acad Sci U S A (2003) [PMID: 12606717  ]
Assembly composition: protein only structure
Assembly name: Protein translocase subunit SecA 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161506 (Preferred)   search this ID
PDBe-KB: P9WGP5   
X-ray diffraction
2.8Å resolution
Released: 4 Mar 2003
Model geometry
Fit model/data
Data not deposited
1nl3
1nl3
1nl3
Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis
Osborne AR, Clemons Jr WM, Rapoport TA
Proc Natl Acad Sci U S A (2004) [PMID: 15256599  ]
Source organism: Bacillus subtilis  
Assembly composition: protein only structure
Bound ligands: MG    ADP    ADP    MG   
Assembly name: Protein translocase subunit SecA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151216 (Preferred)   search this ID
PDBe-KB: P28366   
X-ray diffraction
2.9Å resolution
Released: 3 Aug 2004
Model geometry
Fit model/data
1tf2
1tf2
1tf2
Crystal structure of SecA in an open conformation from Bacillus Subtilis
Osborne AR, Clemons Jr WM, Rapoport TA
Proc Natl Acad Sci U S A (2004) [PMID: 15256599  ]
Source organism: Bacillus subtilis  
Assembly composition: protein only structure
Assembly name: Protein translocase subunit SecA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151216 (Preferred)   search this ID
PDBe-KB: P28366   
X-ray diffraction
2.18Å resolution
Released: 3 Aug 2004
Model geometry
Fit model/data
1tf5
1tf5
1tf5
Complex SecA:ADP from Escherichia coli
Papanikolau Y, Petratos K, Economou A
J Mol Biol (2007) [PMID: 17229438  ]
Source organism: Escherichia coli  
Assembly composition: protein only structure
Bound ligands: ADP    ADP   
Assembly name: Protein translocase subunit SecA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145295 (Preferred)   search this ID
PDBe-KB: P10408   
X-ray diffraction
2.11Å resolution
Released: 16 Jan 2007
Model geometry
Fit model/data
2fsi
2fsi
2fsi
Crystal structure of the SecA translocation ATPase from Bacillus subtilis
Hunt JF, Weinkauf S, Henry L, Fak JJ, McNicholas P, Oliver DB, Deisenhofer J
Science (2002) [PMID: 12242434  ]
Source organism: Bacillus subtilis  
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: Protein translocase subunit SecA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151218 (Preferred)   search this ID
PDBe-KB: P28366   
X-ray diffraction
2.7Å resolution
Released: 20 Sep 2002
Model geometry
Fit model/data
1m6n
1m6n
1m6n
Crystal structure of Mg-ADP-bound SecA from Bacillus subtilis
Hunt JF, Weinkauf S, Henry L, Fak JJ, McNicholas P, Oliver DB, Deisenhofer J
Science (2002) [PMID: 12242434  ]
Source organism: Bacillus subtilis  
Assembly composition: protein only structure
Bound ligands: MG    ADP    ADP    SO4    MG   
Assembly name: Protein translocase subunit SecA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151218 (Preferred)   search this ID
PDBe-KB: P28366   
X-ray diffraction
3Å resolution
Released: 20 Sep 2002
Model geometry
Fit model/data
1m74
1m74
1m74
Complex SecA:ATP from Escherichia coli
Papanikolau Y, Petratos K, Economou A
J Mol Biol (2007) [PMID: 17229438  ]
Source organism: Escherichia coli  
Assembly composition: protein only structure
Bound ligands: ATP    ATP   
Modified residues: MSE    MSE   
Assembly name: Protein translocase subunit SecA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145295 (Preferred)   search this ID
PDBe-KB: P10408   
X-ray diffraction
2.2Å resolution
Released: 16 Jan 2007
Model geometry
Fit model/data
2fsg
2fsg
2fsg
Escherichia coli SecA, the preprotein translocase dimeric ATPase
Papanikolau Y, Petratos K, Economou A
J Mol Biol (2007) [PMID: 17229438  ]
Source organism: Escherichia coli  
Assembly composition: protein only structure
Assembly name: Protein translocase subunit SecA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-145295 (Preferred)   search this ID
PDBe-KB: P10408   
X-ray diffraction
2Å resolution
Released: 16 Jan 2007
Model geometry
Fit model/data
2fsf
2fsf
2fsf
Entries 1 to 10 of 13
Entries 1 to 10 of 13