All structure family : Hemolytic lectin CEL-III, C-terminal domain
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (1)
X-ray diffraction
(4)
 
Authors  (14)
Hatakeyama T
(4)
Eto S
(3)
Kusunoki M
(3)
Uchida T
(3)
Unno H
(3)
Hidemura H
(2)
Kato N
(2)
Kouzuma Y
(2)
Yonekura M
(2)
Goda S
(1)
Kurisu G
(1)
Nakagawa A
(1)
Sugawara H
(1)
Yamasaki T
(1)
 
Homo / hetero assembly  (1)
homo
(4)
 
Assembly composition  (1)
protein structure
(4)
 
Assembly polymer count  (2)
monomer
(3)
heptamer
(1)
 
Resolution distribution
1.5 - 2
(3)
2.5 - 3
(1)
 
Release year distribution
2000 - 2005
(1)
2005 - 2010
(2)
2010 - 2015
(1)
 
Journal  (2)
J Biol Chem
(3)
J. Biol. Chem.
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (1)
Cucumaria echinata
(4)
 
Molecule name  (5)
CEL-III
(4)
Gal/GalNAc-binding lectin CEL-III
(4)
Galactose/N-acetylgalactosamine-binding lectin CEL-III
(4)
Hemolytic lectin CEL-III
(4)
Lectin CEL-III
(4)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (1)
cel3
(4)
 
Interacting ligands  (10)
CA : CALCIUM ION
(4)
MG : MAGNESIUM ION
(4)
A2G : 2-acetamido-2-deoxy-alpha-D-galactopyranose
(1)
AMG : methyl alpha-D-galactopyranoside
(1)
BTB : 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
(1)
CL : CHLORIDE ION
(1)
FRU : beta-D-fructofuranose
(1)
GAL : beta-D-galactopyranose
(1)
NGA : 2-acetamido-2-deoxy-beta-D-galactopyranose
(1)
PRD_900038 : lactulose
(1)
 
Function and Biology
Biological function  (10)
N-acetylgalactosamine binding
(4)
calcium ion binding
(4)
carbohydrate binding
(4)
fucose binding
(4)
galactose binding
(4)
lactose binding
(4)
magnesium ion binding
(4)
melibiose binding
(4)
metal ion binding
(4)
polypeptide N-acetylgalactosaminyltransferase activity
(4)
 
Biological process  (11)
antibacterial humoral response
(4)
cell killing
(4)
defense response to Gram-negative bacterium
(4)
defense response to Gram-positive bacterium
(4)
defense response to bacterium
(4)
disruption of plasma membrane integrity in another organism
(4)
hemolysis in another organism
(4)
killing of cells of another organism
(4)
positive regulation of erythrocyte aggregation
(4)
protein O-linked glycosylation
(4)
protein homooligomerization
(4)
 
Biological cell component  (3)
Golgi apparatus
(4)
extracellular region
(4)
extracellular space
(4)
 
Sequence and Structure classification
SCOP fold  (2)
Hemolytic lectin CEL-III, C-terminal domain
(3)
beta-Trefoil
(3)
 
SCOP family  (2)
Hemolytic lectin CEL-III, C-terminal domain
(3)
Ricin B-like
(3)
 
CATH class  (2)
Alpha Beta
(4)
Mainly Beta
(4)
 
CATH topology  (2)
Trefoil (Acidic Fibroblast Growth Factor, subunit A)
(4)
hemolytic lectin cel-iii, domain 3
(4)
 
Pfam accession / name  (1)
PF00652 : Ricin_B_lectin
(4)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(4)
 
Diffraction radiation source type  (1)
Synchrotron
(4)
 
Diffraction source  (3)
SPRING-8 BEAMLINE BL44XU
(2)
DIAMOND BEAMLINE I03
(1)
PHOTON FACTORY BEAMLINE BL-6A
(1)
 
Synchrotron site  (3)
SPring-8
(2)
Diamond
(1)
Photon Factory
(1)
 
Diffraction detector type  (2)
CCD
(2)
Image plate
(2)
 
Refinement software  (1)
REFMAC
(4)
 
Representative Structures
Representative Structures
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Entries 1 to 4 of 4
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Crystal Structure of Hemolytic Lectin CEL-III
Uchida T, Yamasaki T, Eto S, Sugawara H, Kurisu G, Nakagawa A, Kusunoki M, Hatakeyama T
J Biol Chem (2004) [PMID: 15194688  ]
Source organism: Cucumaria echinata  
Assembly composition: protein only structure
Bound ligands: BTB    MG    CA    BTB    CA    CL    MG   
Modified residues: PCA    PCA   
Assembly name: Galactose/N-acetylgalactosamine-binding lectin CEL-III (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183107 (Preferred)   search this ID
PDBe-KB: Q868M7   
X-ray diffraction
1.7Å resolution
Released: 7 Sep 2004
Model geometry
Fit model/data
1vcl
1vcl
1vcl
Crystal Structure of Hemolytic Lectin CEL-III Complexed with methyl-alpha-D-galactopylanoside
Hatakeyama T, Unno H, Eto S, Hidemura H, Uchida T, Kouzuma Y
J Biol Chem (2007) [PMID: 17977832  ]
Source organism: Cucumaria echinata  
Assembly composition: protein only structure
Bound ligands: MG    CA    AMG    CA    MG    AMG   
Modified residues: PCA    PCA   
Assembly name: Galactose/N-acetylgalactosamine-binding lectin CEL-III (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183107 (Preferred)   search this ID
PDBe-KB: Q868M7   
X-ray diffraction
1.95Å resolution
Released: 30 Oct 2007
Model geometry
Fit model/data
2z49
2z49
2z49
Crystal Structure of Hemolytic Lectin CEL-III Complexed with GalNac
Hatakeyama T, Unno H, Eto S, Hidemura H, Uchida T, Kouzuma Y
J Biol Chem (2007) [PMID: 17977832  ]
Source organism: Cucumaria echinata  
Assembly composition: protein only structure
Bound ligands: MG    CA    CA    A2G    NGA    MG    A2G    NGA   
Modified residues: PCA    PCA   
Assembly name: Galactose/N-acetylgalactosamine-binding lectin CEL-III (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183107 (Preferred)   search this ID
PDBe-KB: Q868M7   
X-ray diffraction
1.7Å resolution
Released: 30 Oct 2007
Model geometry
Fit model/data
2z48
2z48
2z48
pore-forming CEL-III
Unno H, Goda S, Hatakeyama T
J. Biol. Chem. (2014)
Source organism: Cucumaria echinata  
Assembly composition: protein only structure
Bound ligands: MG    CA    CA    MG   
Modified residues: PCA    PCA   
Carbohydrate polymer components:
Molecule 1 - FRU(1), GAL(1)
Assembly name: Galactose/N-acetylgalactosamine-binding lectin CEL-III (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183108 (Preferred)   search this ID
PDBe-KB: Q868M7   
X-ray diffraction
2.9Å resolution
Released: 19 Mar 2014
Model geometry
Fit model/data
3w9t
3w9t
3w9t
Entries 1 to 4 of 4
Entries 1 to 4 of 4