All structure family : Methylated DNA-protein cysteine methyltransferase domain
 
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Entry Information
Entry status  (1)
REL
(24)
 
Experimental methods  (1)
X-ray diffraction
(24)
 
Authors  (58)
Miggiano R
(11)
Perugino G
(11)
Rizzi M
(11)
Rossi F
(11)
Ciaramella M
(10)
Serpe M
(8)
Lahiri S
(7)
Pegg AE
(6)
Valenti A
(6)
Daniels DS
(5)
Garavaglia S
(5)
Rossi M
(5)
Tainer JA
(5)
Vettone A
(4)
Arvai AS
(3)
Bannwarth M
(3)
Johnsson K
(3)
Kanugula S
(3)
Mol CD
(3)
Mollwitz B
(3)
Pav O
(3)
Pohl R
(3)
Pojer F
(3)
Páv O
(3)
Rejman D
(3)
Schiltz M
(3)
Schmitt S
(3)
Casazza V
(2)
Clarke ND
(2)
Luu KX
(2)
Massarotti A
(2)
Moody PC
(2)
Moody PCE
(2)
Morrone C
(2)
Noll DM
(2)
Woo TT
(2)
Del Monaco G
(1)
Demple B
(1)
Dodson EJ
(1)
Duguid EM
(1)
Ferraris DM
(1)
Fujiwara S
(1)
Gulbis JM
(1)
Hashimoto H
(1)
He C
(1)
Imanaka T
(1)
Inoue T
(1)
Kai Y
(1)
Kuroda M
(1)
Moore MH
(1)
Nakamura KT
(1)
Nishioka M
(1)
Rice PA
(1)
Rizzii M
(1)
Takagi M
(1)
Tsunoda M
(1)
Wibley JE
(1)
Wibley JEA
(1)
 
Homo / hetero assembly  (2)
homo
(19)
hetero
(5)
 
Assembly composition  (2)
protein structure
(19)
DNA/protein complex
(5)
 
Assembly polymer count  (3)
monomer
(19)
trimer
(4)
pentamer
(1)
 
Resolution distribution
1.5 - 2
(11)
2.0 - 2.5
(3)
2.5 - 3
(7)
3.0 - 3.5
(3)
 
Release year distribution
1995 - 2000
(6)
2000 - 2005
(8)
2005 - 2010
(5)
2010 - 2015
(12)
2015 - 2020
(9)
 
Journal  (9)
Nucleic Acids Res
(5)
EMBO J
(4)
To be published
(4)
Biochem J
(3)
J Bacteriol
(2)
J Mol Biol
(2)
Nat Struct Mol Biol
(2)
Biochem Biophys Res Commun
(1)
Biochim Biophys Acta Gen Subj
(1)
 
Macromolecules
Organism superkingdom  (3)
Eukaryota
(10)
Archaea
(8)
Bacteria
(6)
 
Organism name  (7)
Homo sapiens
(10)
Mycobacterium tuberculosis H37Rv
(5)
Saccharolobus solfataricus
(3)
Saccharolobus solfataricus P2
(3)
Escherichia coli B
(1)
Sulfurisphaera tokodaii
(1)
Thermococcus kodakarensis KOD1
(1)
 
Molecule name  (12)
Methylated-DNA--protein-cysteine methyltransferase
(22)
6-O-methylguanine-DNA methyltransferase
(21)
O-6-methylguanine-DNA-alkyltransferase
(21)
MGMT
(20)
SNAP-tag
(2)
Bifunctional transcriptional activator/DNA repair enzyme Ada
(1)
Methylphosphotriester-DNA methyltransferase
(1)
Methylphosphotriester-DNA--protein-cysteine S-methyltransferase
(1)
O6-alkylguanine-DNA alkyltransferase mutant
(1)
O6-methylguanine-DNA alkyltransferase
(1)
Pk-MGMT
(1)
Regulatory protein of adaptive response
(1)
 
Molecule type  (1)
Protein
(24)
 
Gene names  (11)
ogt
(13)
MGMT
(7)
SSO2487
(6)
MTCY130.01c
(5)
Rv1316c
(5)
JW2201
(1)
STK_09670
(1)
TK1971
(1)
ada
(1)
b2213
(1)
mgtk
(1)
 
Interacting Molecules  (9)
5'-D(*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3'
(2)
5'-D(*CP*CP*TP*AP*CP*AP*CP*AP*CP*AP*TP*CP*CP*AP*CP*A)-3'
(1)
5'-D(*GP*CP*CP*AP*TP*GP*(6OG)P*CP*TP*AP*GP*TP*A)-3'
(1)
5'-D(*GP*CP*CP*AP*TP*GP*(E1X)P*CP*TP*AP*GP*TP*A)-3'
(1)
5'-D(*GP*TP*GP*GP*AP*TP*GP*(XCY)P*GP*TP*GP*TP*AP*GP*GP*T)-3'
(1)
DNA (5'-D(*GP*CP*CP*AP*TP*GP*(6OG)P*CP*TP*AP*GP*TP*A)-3')
(1)
DNA (5'-D(*GP*CP*CP*AP*TP*GP*(E1X)P*CP*TP*AP*GP*TP*A)-3')
(1)
DNA (5'-D(*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3')
(1)
DNA (5'-D(P*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3')
(1)
 
Interacting ligands  (7)
ZN : ZINC ION
(7)
GOL : GLYCEROL
(5)
SO4 : SULFATE ION
(2)
EDO : 1,2-ETHANEDIOL
(1)
ETW : 5-[(4-methylphenyl)methylcarbamoyl]-2-(6-oxidanyl-3-oxidanylidene-4~{H}-xanthen-9-yl)benzoic acid
(1)
NO3 : NITRATE ION
(1)
OBG : 6-(benzyloxy)-9H-purin-2-amine
(1)
 
Function and Biology
EC number / name  (2)
2.1.1.63 : Methylated-DNA--[protein]-cysteine S-methyltransferase
(22)
2.1.1.n11 : Methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase
(1)
 
Biological function  (6)
catalytic activity
(24)
methylated-DNA-[protein]-cysteine S-methyltransferase activity
(24)
methyltransferase activity
(17)
DNA binding
(4)
metal ion binding
(4)
DNA-methyltransferase activity
(3)
 
Biological process  (8)
DNA repair
(24)
DNA metabolic process
(17)
methylation
(17)
DNA alkylation repair
(16)
response to nitrosative stress
(5)
DNA damage response
(3)
negative regulation of apoptotic process
(3)
positive regulation of double-strand break repair
(3)
 
Biological cell component  (5)
cytoplasm
(13)
plasma membrane
(5)
nucleus
(4)
membrane
(3)
nucleoplasm
(3)
 
Sequence and Structure classification
SCOP fold  (2)
DNA/RNA-binding 3-helical bundle
(9)
Ribonuclease H-like motif
(9)
 
SCOP family  (2)
Methylated DNA-protein cysteine methyltransferase domain
(9)
Methylated DNA-protein cysteine methyltransferase, C-terminal domain
(9)
 
CATH class  (2)
Alpha Beta
(24)
Mainly Alpha
(24)
 
CATH topology  (2)
Arc Repressor Mutant, subunit A
(24)
Double Stranded RNA Binding Domain
(24)
 
Pfam accession / name  (3)
PF01035 : DNA_binding_1
(22)
PF02870 : Methyltransf_1N
(21)
PF09153 : MGMT_N
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(23)
 
Diffraction radiation source type  (2)
Synchrotron
(24)
Rotating anode
(1)
 
Diffraction source  (15)
ESRF BEAMLINE BM30A
(3)
ESRF BEAMLINE ID23-1
(3)
ESRF BEAMLINE ID29
(3)
SSRL BEAMLINE BL9-1
(3)
ESRF BEAMLINE ID14-4
(2)
SSRL BEAMLINE BL7-1
(2)
APS BEAMLINE 14-BM-C
(1)
ESRF BEAMLINE ID14-1
(1)
ESRF BEAMLINE ID14-3
(1)
ESRF BEAMLINE ID23-2
(1)
PHOTON FACTORY BEAMLINE AR-NW12A
(1)
PHOTON FACTORY BEAMLINE BL-18B
(1)
PHOTON FACTORY BEAMLINE BL-6A
(1)
RIGAKU RU300
(1)
SRS BEAMLINE PX9.6
(1)
 
Synchrotron site  (5)
ESRF
(14)
SSRL
(5)
Photon Factory
(3)
APS
(1)
SRS
(1)
 
Diffraction detector type  (4)
CCD
(10)
Pixel
(6)
Image plate
(4)
Diffractometer
(2)
 
Refinement software  (4)
PHENIX
(9)
CNS
(7)
REFMAC
(7)
PROLSQ
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 24
Entries 1 to 10 of 24
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wt Human O6-Alkylguanine-DNA Alkyltransferase Bound To DNA Containing an Alkylated Cytosine
Duguid EM, Rice PA, He C
J Mol Biol (2005) [PMID: 15964013  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: DNA/protein complex
Bound ligands: ZN    ZN   
Modified residues: XCY    XCY   
Assembly name: Methylated-DNA--protein-cysteine methyltransferase and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-114860 (Preferred)   search this ID
PDBe-KB: P16455   
X-ray diffraction
3.01Å resolution
Released: 13 Dec 2005
Model geometry
Fit model/data
1yfh
1yfh
1yfh
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE COVALENTLY CROSSLINKED TO DNA
Daniels DS, Woo TT, Luu KX, Noll DM, Clarke ND, Pegg AE, Tainer JA
Nat Struct Mol Biol (2004) [PMID: 15221026  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: DNA/protein complex
Modified residues: E1X    E1X   
Assembly name: Methylated-DNA--protein-cysteine methyltransferase and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-114629 (Preferred)   search this ID
PDBe-KB: P16455   
X-ray diffraction
3.3Å resolution
Released: 13 Jul 2004
Model geometry
Fit model/data
1t39
1t39
1t39
BENZYLATED HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Daniels DS, Tainer JA
EMBO J (2000) [PMID: 10747039  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Modified residues: BCS    BCS   
Assembly name: Methylated-DNA--protein-cysteine methyltransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-147730 (Preferred)   search this ID
PDBe-KB: P16455   
X-ray diffraction
2.5Å resolution
Released: 12 Apr 2000
Model geometry
Fit model/data
Data not deposited
1eh8
1eh8
1eh8
METHYLATED HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Daniels DS, Tainer JA
EMBO J (2000) [PMID: 10747039  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Modified residues: SMC    SMC   
Assembly name: Methylated-DNA--protein-cysteine methyltransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-147730 (Preferred)   search this ID
PDBe-KB: P16455   
X-ray diffraction
2Å resolution
Released: 12 Apr 2000
Model geometry
Fit model/data
Data not deposited
1eh7
1eh7
1eh7
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Daniels DS, Tainer JA
EMBO J (2000) [PMID: 10747039  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: ZN    ZN   
Assembly name: Methylated-DNA--protein-cysteine methyltransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-147730 (Preferred)   search this ID
PDBe-KB: P16455   
X-ray diffraction
2Å resolution
Released: 12 Apr 2000
Model geometry
Fit model/data
Data not deposited
1eh6
1eh6
1eh6
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BOUND TO DNA CONTAINING O6-METHYLGUANINE
Daniels DS, Woo TT, Luu KX, Noll DM, Clarke ND, Pegg AE, Tainer JA
Nat Struct Mol Biol (2004) [PMID: 15221026  ]
Source organisms: Synthetic construct, Homo sapiens  
Assembly composition: DNA/protein complex
Modified residues: 6OG    6OG   
Assembly name: Methylated-DNA--protein-cysteine methyltransferase and DNA (Preferred)   search this complex
PDBe complex ID: PDB-CPX-114628 (Preferred)   search this ID
PDBe-KB: P16455   
X-ray diffraction
3.2Å resolution
Released: 13 Jul 2004
Model geometry
Fit model/data
1t38
1t38
1t38
ADA O6-METHYLGUANINE-DNA METHYLTRANSFERASE FROM ESCHERICHIA COLI
Moore MH, Gulbis JM, Dodson EJ, Demple B, Moody PCE
EMBO J (1994) [PMID: 8156986  ]
Source organism: Escherichia coli B  
Assembly composition: protein only structure
Assembly name: Bifunctional transcriptional activator/DNA repair enzyme Ada (Preferred)   search this complex
PDBe complex ID: PDB-CPX-138880 (Preferred)   search this ID
PDBe-KB: P06134   
X-ray diffraction
2.1Å resolution
Released: 23 Dec 1996
Model geometry
Fit model/data
1sfe
1sfe
1sfe
CRYSTAL STRUCTURE OF O6-METHYLGUANINE-DNA METHYLTRANSFERASE FROM HYPERTHERMOPHILIC ARCHAEON PYROCOCCUS KODAKARAENSIS STRAIN KOD1
Hashimoto H, Inoue T, Nishioka M, Fujiwara S, Takagi M, Imanaka T, Kai Y
J Mol Biol (1999) [PMID: 10497033  ]
Assembly composition: protein only structure
Bound ligands: SO4   
Assembly name: Methylated-DNA--protein-cysteine methyltransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-130750 (Preferred)   search this ID
PDBe-KB: O74023   
X-ray diffraction
1.8Å resolution
Released: 7 Jan 2000
Model geometry
Fit model/data
1mgt
1mgt
1mgt
X-ray structure of human O6alkylguanine-DNA alkyltransferase
Wibley JEA, Moody PCE
Nucleic Acids Res (2000) [PMID: 10606635  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Methylated-DNA--protein-cysteine methyltransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-147730 (Preferred)   search this ID
PDBe-KB: P16455   
X-ray diffraction
1.9Å resolution
Released: 16 Dec 1999
Model geometry
Fit model/data
Data not deposited
1qnt
1qnt
1qnt
Crystal structure of O6-methylguanine methyltransferase from Sulfolobus tokodaii
Kuroda M, Tsunoda M, Nakamura KT
To be published
Assembly composition: protein only structure
Assembly name: Methylated-DNA--protein-cysteine methyltransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-188827 (Preferred)   search this ID
PDBe-KB: Q973C7   
X-ray diffraction
2Å resolution
Released: 6 Dec 2005
Model geometry
Fit model/data
Data not deposited
1wrj
1wrj
1wrj
Entries 1 to 10 of 24
Entries 1 to 10 of 24