Entry status  (1)

REL

(622)

Experimental methods  (1)

X-ray diffraction

(622)

Authors  (301)

Poulos TL

(544)

Li H

(492)

Silverman RB

(486)

Martasek P

(272)

Martásek P

(257)

Roman LJ

(236)

Chreifi G

(193)

Cinelli MA

(115)

Xue F

(109)

Kang S

(108)

Huang H

(96)

Jamal J

(91)

Delker SL

(90)

Jing Q

(87)

Ji H

(77)

Pensa AV

(77)

Holden JK

(71)

Do HT

(63)

Mukherjee P

(55)

Lewis MC

(52)

Stuehr DJ

(44)

Getzoff ED

(41)

Tainer JA

(41)

Fang J

(40)

Tang W

(39)

Raman CS

(38)

Crane BR

(37)

Dejam D

(34)

Wang HY

(34)

Masters BSS

(32)

Arvai AS

(31)

Rosenfeld RJ

(30)

Wallace AV

(28)

Yang W

(28)

Aberg A

(27)

Andersson G

(27)

Garcin ED

(27)

Labby KJ

(27)

Masters BS

(24)

Igarashi J

(23)

Abdullatif Z

(22)

Plaza C

(22)

Sevrioukova I

(21)

Andrews G

(18)

Cheshire DR

(18)

Connolly S

(18)

Hamley PJ

(18)

Mete A

(18)

Nicholls DJ

(18)

St-Gallay SA

(18)

Gensmantel NP

(17)

Ghosh DK

(17)

Kraus JM

(17)

Kroeger MD

(17)

Mallinder PR

(17)

Mataka J

(17)

Tinker AC

(17)

Delker S

(16)

Wang H

(16)

Doukov T

(13)

Flinspach ML

(13)

Gomez-Vidal JA

(13)

Gómez-Vidal JA

(13)

Litzinger EA

(13)

Qin Y

(13)

Meyskens FL

(12)

Yang S

(12)

Lim N

(11)

Soltis M

(11)

Southan GJ

(11)

Martell JD

(10)

Morris GM

(10)

Olson AJ

(10)

Panda K

(10)

Chen S

(9)

Fedorov R

(9)

Hollingsworth SA

(9)

Schlichting I

(9)

Whitlow M

(9)

Hah JM

(8)

Pant K

(8)

Adler M

(7)

Devlin JJ

(7)

Erickson S

(7)

Flinspach M

(7)

Ghosh S

(7)

Hah J-M

(7)

Huiying L

(7)

Kral V

(7)

Král V

(7)

Morrissey MM

(7)

Pan G

(7)

Stueh DJ

(7)

Thomas LP

(7)

Vergona R

(7)

Arnaiz D

(6)

Chen Y

(6)

Choing S

(6)

Davey DD

(6)

Doud EH

(6)

 

More...

Homo / hetero assembly  (2)

homo

(619)

hetero

(3)

Assembly composition  (2)

protein structure

(619)

protein/protein complex

(3)

Assembly polymer count  (4)

dimer

(611)

monomer

(7)

tetramer

(3)

trimer

(1)

Resolution distribution

1.5 - 2

(291)

2.0 - 2.5

(287)

2.5 - 3

(38)

3.0 - 3.5

(6)

Release year distribution

1995 - 2000

(29)

2000 - 2005

(88)

2005 - 2010

(102)

2010 - 2015

(307)

2015 - 2020

(244)

Journal  (23)

J Med Chem

(269)

Biochemistry

(155)

J Am Chem Soc

(51)

Bioorg Med Chem

(22)

Bioorg Med Chem Lett

(20)

J Biol Chem

(19)

Nat Chem Biol

(17)

To be published

(14)

J Biol Inorg Chem

(8)

Nat Struct Mol Biol

(8)

Proc Natl Acad Sci U S A

(7)

Science

(6)

Cell

(4)

Chem Biol

(4)

Acta Crystallogr D Biol Crystallogr

(3)

J Inorg Biochem

(3)

J Mol Biol

(3)

ACS Med Chem Lett

(2)

EMBO J

(2)

Nat Struct Biol

(2)

Arch Biochem Biophys

(1)

Org Biomol Chem

(1)

Structure

(1)

Organism superkingdom  (2)

Eukaryota

(544)

Bacteria

(78)

Organism name  (8)

Rattus norvegicus

(264)

Bos taurus

(137)

Homo sapiens

(94)

Bacillus subtilis subsp. subtilis str. 168

(58)

Mus musculus

(49)

Bacillus subtilis

(18)

Geobacillus stearothermophilus

(1)

Staphylococcus aureus

(1)

Molecule name  (33)

Constitutive NOS

(489)

N-NOS

(331)

NC-NOS

(331)

NOS type I

(331)

Neuronal NOS

(331)

Nitric oxide synthase 1

(331)

Nitric oxide synthase, brain

(331)

Peptidyl-cysteine S-nitrosylase NOS1

(331)

bNOS

(331)

nNOS

(331)

EC-NOS

(158)

Endothelial NOS

(158)

NOS type III

(158)

NOSIII

(158)

Nitric oxide synthase 3

(158)

Nitric oxide synthase, endothelial

(158)

cNOS

(158)

eNOS

(158)

NOSoxy-like protein

(77)

Nitric oxide synthase oxygenase

(77)

Inducible NO synthase

(55)

Inducible NOS

(55)

NOS type II

(55)

Nitric oxide synthase, inducible

(55)

Peptidyl-cysteine S-nitrosylase NOS2

(55)

iNOS

(55)

MAC-NOS

(49)

Macrophage NOS

(49)

HEP-NOS

(6)

Hepatocyte NOS

(6)

Nitric oxide synthase

(1)

Nitric oxide synthase (NOS) domain-containing protein

(1)

SANOS

(1)

Molecule type  (1)

Protein

(622)

Gene names  (12)

Bnos

(274)

Nos1

(274)

NOS3

(158)

nos

(77)

BSU07630

(76)

yflM

(76)

NOS1

(57)

Inosl

(49)

Nos2

(49)

NOS2

(6)

NOS2A

(6)

GK1676

(1)

Interacting Molecules  (1)

Nitric oxide synthase 3

(3)

Interacting ligands  (316)

HEM : PROTOPORPHYRIN IX CONTAINING FE

(618)

H4B : 5,6,7,8-TETRAHYDROBIOPTERIN

(529)

ZN : ZINC ION

(499)

ACT : ACETATE ION

(379)

GOL : GLYCEROL

(239)

CL : CHLORIDE ION

(101)

CAD : CACODYLIC ACID

(46)

ARG : ARGININE

(31)

BTB : 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL

(26)

CAC : CACODYLATE ION

(25)

SO4 : SULFATE ION

(24)

GD : GADOLINIUM ATOM

(23)

EDO : 1,2-ETHANEDIOL

(17)

POL : N-PROPANOL

(17)

MTL : D-MANNITOL

(14)

HAR : N-OMEGA-HYDROXY-L-ARGININE

(12)

NO : NITRIC OXIDE

(10)

PEG : DI(HYDROXYETHYL)ETHER

(10)

ITU : ETHYLISOTHIOUREA

(9)

XFJ : 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine)

(9)

XFN : 6,6'-[(5-aminobenzene-1,3-diyl)diethane-2,1-diyl]bis(4-methylpyridin-2-amine)

(9)

HBI : 7,8-DIHYDROBIOPTERIN

(8)

BOG : octyl beta-D-glucopyranoside

(7)

DP9 : L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE

(6)

INE : 3-BROMO-7-NITROINDAZOLE

(6)

Q16 : 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine

(6)

XEB : 7-[[4-chloranyl-3-(methylaminomethyl)phenoxy]methyl]quinolin-2-amine

(6)

8FD : 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2S)-2-(methylamino)propyl]benzonitrile

(5)

DP1 : L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE

(5)

EXI : N1-(5-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)-N1,N2-dimethylethane-1,2-diamine

(5)

H2B : 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE

(5)

HW1 : 6-[5-({(3R,4R)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}oxy)pentyl]-4-methylpyridin-2-amine

(5)

HW9 : 4-methyl-6-{[(3R,4R)-4-{[5-(4-methylpyridin-2-yl)pentyl]oxy}pyrrolidin-3-yl]methyl}pyridin-2-amine

(5)

IMD : IMIDAZOLE

(5)

JI5 : N-{(3R,4R)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine

(5)

JRR : 6-{[(3R,4R)-4-(2-{[2-(3-fluorophenyl)ethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine

(5)

M48 : 7-[2-[2-(3-fluorophenyl)ethylamino]ethyl]quinolin-2-amine

(5)

M4R : 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2R)-2-(methylamino)propyl]benzonitrile

(5)

M85 : 7-[[3-(methylaminomethyl)phenoxy]methyl]quinolin-2-amine

(5)

XFK : 6-(2-{5-[2-(2-amino-6-methylpyridin-4-yl)ethyl]pyridin-3-yl}ethyl)-4-methylpyridin-2-amine

(5)

2SN : 7-[[[3-[(dimethylamino)methyl]phenyl]amino]methyl]quinolin-2-amine

(4)

8EY : 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile

(4)

8VJ : 7-[[4-[(dimethylamino)methyl]phenoxy]methyl]quinolin-2-amine

(4)

9OJ : 4-(2-{[(2-amino-4-methylquinolin-7-yl)methyl]amino}ethyl)-2-methylbenzonitrile

(4)

9P7 : 4-(2-{[(2-aminoquinolin-7-yl)methyl]amino}ethyl)-2-methylbenzonitrile

(4)

AT2 : ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE

(4)

HW8 : 4-methyl-6-{[(3R,4R)-4-{[5-(pyridin-2-yl)pentyl]oxy}pyrrolidin-3-yl]methyl}pyridin-2-amine

(4)

JI4 : N-{(3S,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine

(4)

JSS : 6-{[(3S,4S)-4-(2-{[2-(3-fluorophenyl)ethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine

(4)

M94 : 7-[[3-[2-(methylamino)ethyl]phenoxy]methyl]quinolin-2-amine

(4)

NRG : N-OMEGA-NITRO-L-ARGININE

(4)

Q1T : 3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)-5-(METHYL(2-(METHYLAMINO)ETHYL)AMINO)BENZONITRILE

(4)

W64 : 4-methyl-6-(2-(5-(4-methylpiperazin-1-yl)pyridin-3-yl)ethyl)pyridin-2-amine

(4)

W67 : 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE

(4)

XH8 : 7-(((3-(PYRIDIN-3-YL)PROPYL)AMINO)METHYL)QUINOLIN-2-

(4)

0GD : 6-[4-({[2-(3-fluorophenyl)ethyl]amino}methyl)phenyl]-4-methylpyridin-2-amine

(3)

14W : N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE

(3)

1EV : 3,5-bis[2-(6-amino-4-methylpyridin-2-yl)ethyl]benzonitrile

(3)

1Q6 : 6,6'-{[(2S)-3-aminopropane-1,2-diyl]bis(oxymethanediyl)}bis(4-methylpyridin-2-amine)

(3)

1QF : N-(4-{2-[ethyl(3-{[(E)-imino(thiophen-2-yl)methyl]amino}benzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide

(3)

3AR : N-OMEGA-PROPYL-L-ARGININE

(3)

4V4 : N1-(3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)phenyl)-N1,N2-dimethylethane-1,2-diamine

(3)

5H4 : N-[3-({ethyl[2-(3-fluorophenyl)ethyl]amino}methyl)phenyl]thiophene-2-carboximidamide

(3)

6E5 : N-[3-({[(3S,5S)-5-{[(3-{[(Z)-imino(thiophen-2-yl)methyl]amino}benzyl)oxy]methyl}pyrrolidin-3-yl]oxy}methyl)phenyl]thiophene-2-carboximidamide

(3)

7LN : N,N''-{[(2S)-3-aminopropane-1,2-diyl]bis(oxymethanediylbenzene-3,1-diyl)}dithiophene-2-carboximidamide

(3)

7NI : 7-NITROINDAZOLE

(3)

8EV : 3-[(2-aminoquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile

(3)

8J4 : 7-({3-ethyl-5-[(methylamino)methyl]phenoxy}methyl)quinolin-2-amine

(3)

9M9 : 7-[[3-(aminomethyl)phenoxy]methyl]quinolin-2-amine

(3)

9OG : 4-(2-{[(2-amino-4-methylquinolin-7-yl)methyl]amino}ethyl)benzonitrile

(3)

CMO : CARBON MONOXIDE

(3)

HEC : HEME C

(3)

I5U : N',N'-{[(2R)-3-aminopropane-1,2-diyl]bis(oxymethanediylbenzene-3,1-diyl)}dithiophene-2-carboximidamide

(3)

J11 : N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine

(3)

J14 : N-{(3S,4R)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine

(3)

JHT : 7-[[[3-(dimethylamino)phenyl]methylamino]methyl]quinolin-2-amine

(3)

JM7 : N~5~-[2-(ethylsulfanyl)ethanimidoyl]-L-ornithine

(3)

JRS : 6-{[(3S,4R)-4-(2-{[2-(3-fluorophenyl)ethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine

(3)

KL4 : 6-[2-(3-fluoro-5-{2-[(2S)-pyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine

(3)

KL7 : 6-(2-{3-[3-(dimethylamino)propyl]-2,6-difluorophenyl}ethyl)-4-methylpyridin-2-amine

(3)

KLD : 6-[2-(3-fluoro-5-{2-[(2R,4S)-4-fluoro-1-methylpyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine

(3)

KLY : 6-(2-{3-fluoro-5-[3-(methylamino)prop-1-yn-1-yl]phenyl}ethyl)-4-methylpyridin-2-amine

(3)

KMA : 6-[2-(3-fluoro-5-{2-[(2R)-pyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine

(3)

KMM : 6-(2-{3-[3-(dimethylamino)propyl]-2,5,6-trifluorophenyl}ethyl)-4-methylpyridin-2-amine

(3)

KMS : 6-(2-{5-[3-(dimethylamino)propyl]-2,3,4-trifluorophenyl}ethyl)-4-methylpyridin-2-amine

(3)

KNV : 6-[2-(2,3-difluoro-5-{2-[(2S)-1-methylazetidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine

(3)

M87 : 7-[[2-(3-fluorophenyl)ethylamino]methyl]quinolin-2-amine

(3)

MPD : (4S)-2-METHYL-2,4-PENTANEDIOL

(3)

OLW : 3-[({2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}amino)methyl]benzonitrile

(3)

P64 : 7-[({2-[4-(dimethylamino)phenyl]ethyl}amino)methyl]quinolin-2-amine

(3)

P94 : 4-(2-{[(2-aminoquinolin-7-yl)methyl]amino}ethyl)benzonitrile

(3)

PQW : N'-[4-[[(2S,4R)-4-[3-[(C-thiophen-2-ylcarbonimidoyl)amino]phenoxy]pyrrolidin-2-yl]methoxy]phenyl]thiophene-2-carboximidamide

(3)

Q13 : 6,6'-{[(2S,3S)-2-aminobutane-1,3-diyl]bis(oxymethanediyl)}bis(4-methylpyridin-2-amine)

(3)

Q14 : 6-[({(2S)-1-amino-4-[(6-amino-4-methylpyridin-2-yl)methoxy]butan-2-yl}oxy)methyl]-4-methylpyridin-2-amine

(3)

QJ7 : 6-({[5-({[2-(3-fluorophenyl)ethyl]amino}methyl)pyridin-3-yl]oxy}methyl)-4-methylpyridin-2-amine

(3)

QJ8 : 6-({[(3R,5S)-5-{[(6-amino-4-methylpyridin-2-yl)methoxy]methyl}pyrrolidin-3-yl]oxy}methyl)-4-methylpyridin-2-amine

(3)

RFQ : N-{3-[(1S)-2-(3-{(Z)-[amino(thiophen-2-yl)methylidene]amino}phenoxy)-1-hydroxyethyl]phenyl}thiophene-2-carboximidamide

(3)

S5D : (R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine

(3)

S71 : (R)-6-(3-amino-2-(5-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)propyl)-4-methylpyridin-2-amine

(3)

TUE : 7-[[5-[(methylideneamino)methyl]pyridin-3-yl]oxymethyl]quinolin-2-amine

(3)

 

More...

EC number / name  (2)

1.14.13.39 : Nitric-oxide synthase (NADPH)

(545)

1.14.14.47 : Nitric-oxide synthase (flavodoxin)

(77)

Biological function  (4)

nitric-oxide synthase activity

(622)

heme binding

(139)

metal ion binding

(77)

oxidoreductase activity

(77)

Biological process  (1)

nitric oxide biosynthetic process

(622)

Compound cofactor class  (4)

Heme

(622)

Biopterin

(53)

Tetrahydrofolic acid

(2)

Nicotinamide-adenine dinucleotide

(1)

SCOP fold  (1)

Nitric oxide (NO) synthase oxygenase domain

(127)

SCOP family  (1)

Nitric oxide (NO) synthase oxygenase domain

(127)

CATH class  (1)

Alpha Beta

(622)

CATH topology  (3)

Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3

(622)

Nitric Oxide Synthase; Chain A, domain 1

(622)

Nitric Oxide Synthase;Heme Domain; Chain A, domain 2

(622)

Pfam accession / name  (1)

PF02898 : NO_synthase

(622)

Diffraction protocol  (1)

Single wavelength

(611)

Diffraction radiation source type  (2)

Synchrotron

(620)

Rotating anode

(2)

Diffraction source  (33)

SSRL BEAMLINE BL7-1

(218)

ALS BEAMLINE 8.2.1

(72)

SSRL BEAMLINE BL9-2

(69)

SSRL BEAMLINE BL14-1

(45)

ALS BEAMLINE 8.2.2

(43)

ALS BEAMLINE 5.0.2

(37)

SSRL BEAMLINE BL9-1

(36)

SSRL BEAMLINE BL11-1

(34)

SSRL BEAMLINE BL12-2

(16)

SSRL BEAMLINE BL1-5

(12)

CHESS BEAMLINE F1

(6)

CHESS BEAMLINE F2

(6)

ESRF BEAMLINE ID14-1

(4)

NSLS BEAMLINE X25

(4)

APS BEAMLINE 14-BM-C

(3)

ESRF BEAMLINE ID14-2

(3)

ALS BEAMLINE 5.0.1

(2)

NSLS BEAMLINE X12C

(2)

ALS BEAMLINE 12.3.1

(1)

ALS BEAMLINE 4.2.2

(1)

APS BEAMLINE 17-BM

(1)

APS BEAMLINE 17-ID

(1)

EMBL/DESY, HAMBURG BEAMLINE X13

(1)

EMBL/DESY, HAMBURG BEAMLINE X31

(1)

ESRF BEAMLINE BM14

(1)

ESRF BEAMLINE ID14-3

(1)

ESRF BEAMLINE ID14-4

(1)

ESRF BEAMLINE ID29

(1)

MAX II BEAMLINE I711

(1)

NSLS BEAMLINE X26C

(1)

RIGAKU MICROMAX-007 HF

(1)

RIGAKU RUH2R

(1)

SSRL BEAMLINE BL9-3

(1)

Synchrotron site  (8)

SSRL

(431)

ALS

(156)

CHESS

(12)

ESRF

(11)

NSLS

(6)

APS

(5)

EMBL/DESY, Hamburg

(2)

MAX II

(1)

Diffraction detector type  (3)

CCD

(477)

Pixel

(74)

Image plate

(71)

Refinement software  (7)

PHENIX

(259)

REFMAC

(221)

CNS

(181)

X-PLOR

(26)

CNX

(4)

SHELXL-97

(2)

BUSTER

(1)

Representative Structures

100%

95%

90%

70%

50%

40%

30%