Entries released this week  (1)

revised

(1)

Entry status  (1)

REL

(124)

Experimental methods  (2)

X-ray diffraction

(121)

Electron Microscopy

(3)

Authors  (398)

Fothergill-Gilmore LA

(30)

Walkinshaw MD

(30)

Morgan HP

(26)

McNae IW

(25)

Leslie AG

(21)

Michels PA

(21)

Michels PAM

(21)

Walker JE

(21)

Leslie AGW

(19)

Montgomery MG

(16)

Nowicki MW

(15)

Zhong W

(13)

Arrowsmith CH

(11)

Structural Genomics Consortium (SGC)

(11)

Bochkarev A

(10)

Edwards AM

(10)

Weigelt J

(10)

Bountra C

(9)

Mueller DM

(9)

Wear MA

(9)

Auld DS

(8)

Yuan M

(8)

Mattevi A

(7)

Park H

(7)

Symersky J

(7)

Valentini G

(7)

Boxer M

(6)

Dimov S

(6)

Fortin R

(6)

Galizzi A

(6)

Hong B

(6)

Tempel W

(6)

Auld D

(5)

Bason JV

(5)

Cantley LC

(5)

Hannaert V

(5)

Hupp T

(5)

Inglese J

(5)

Jianq J-K

(5)

Min S

(5)

Pizarro JC

(5)

Skoumbourdis A

(5)

Southall N

(5)

Sun C

(5)

Thomas C

(5)

Vander Heiden MG

(5)

Wang P

(5)

Xu Y

(5)

Zhu T

(5)

Abraham DJ

(4)

Arsenieva D

(4)

Asara JM

(4)

Bella J

(4)

Bianchi P

(4)

Blackburn EA

(4)

Bowler MW

(4)

Chiarelli L

(4)

Chiarelli LR

(4)

Christofk HR

(4)

Dolzan M

(4)

Fenton AW

(4)

Gledhill JR

(4)

Hills T

(4)

Holyoak T

(4)

Hui R

(4)

Larsen TM

(4)

Pagadala V

(4)

Rayment I

(4)

Reed GH

(4)

Wang C

(4)

Wang Y

(4)

Wernimont AK

(4)

Zanella A

(4)

Allali-Hassani A

(3)

Bakszt R

(3)

Benning MM

(3)

Chen Y

(3)

Cossar D

(3)

Dang L

(3)

Finlay BB

(3)

Gong H

(3)

Jin S

(3)

Kaur S

(3)

Kung C

(3)

Kunii K

(3)

McMaster WR

(3)

O'Reilly F

(3)

Palmer R

(3)

Reiner NE

(3)

Salituro FG

(3)

See RH

(3)

Shen M

(3)

Speranza ML

(3)

Strynadka NC

(3)

Strynadka NCJ

(3)

Vedadi M

(3)

Vuckovic M

(3)

Worrall LJ

(3)

Yang H

(3)

Zoraghi R

(3)

 

More...

Homo / hetero assembly  (2)

homo

(88)

hetero

(36)

Assembly composition  (2)

protein structure

(88)

protein/protein complex

(36)

Assembly polymer count  (14)

tetramer

(79)

nonamer

(15)

dimer

(6)

decamer

(4)

heptamer

(4)

monomer

(3)

nonadecamer

(3)

27-mer

(2)

hexamer

(2)

octamer

(2)

29-mer

(1)

60-mer

(1)

heptadecamer

(1)

tridecamer

(1)

Resolution distribution

1.0 - 1.5

(2)

1.5 - 2

(14)

2.0 - 2.5

(44)

2.5 - 3

(35)

3.0 - 3.5

(21)

3.5 - 4

(8)

Release year distribution

1990 - 1995

(3)

1995 - 2000

(12)

2000 - 2005

(12)

2005 - 2010

(48)

2010 - 2015

(61)

2015 - 2020

(23)

Journal  (30)

J Biol Chem

(23)

To be published

(17)

Proc Natl Acad Sci U S A

(15)

Biochemistry

(8)

Biochem J

(7)

Acta Crystallogr D Biol Crystallogr

(5)

J Mol Biol

(5)

Protein Cell

(5)

Science

(4)

Structure

(4)

Nature

(3)

PLoS One

(3)

Acta Crystallogr Sect F Struct Biol Cryst Commun

(2)

Bioorg Med Chem

(2)

Commun Biol

(2)

EMBO J

(2)

Nat Chem Biol

(2)

Nat Struct Biol

(2)

R Soc Open Sci

(2)

ACS Chem Biol

(1)

Acta Crystallogr D Struct Biol

(1)

Arch Biochem Biophys

(1)

Bioorg Med Chem Lett

(1)

Cell

(1)

Chem Biol

(1)

Insect Biochem Mol Biol

(1)

J Biochem

(1)

Mol Cell

(1)

Open Biol

(1)

Protein Sci

(1)

Organism superkingdom  (3)

Eukaryota

(108)

Bacteria

(13)

Archaea

(3)

Organism name  (25)

Homo sapiens

(38)

Bos taurus

(18)

Leishmania mexicana

(13)

Saccharomyces cerevisiae

(11)

Oryctolagus cuniculus

(8)

Trypanosoma brucei brucei

(6)

Escherichia coli

(5)

Saccharomyces cerevisiae S288C

(3)

Staphylococcus aureus subsp. aureus MRSA252

(3)

Cryptosporidium parvum Iowa II

(2)

Toxoplasma gondii

(2)

Trypanosoma cruzi strain CL Brener

(2)

Aedes aegypti

(1)

Archaeoglobus fulgidus DSM 4304

(1)

Bacillus sp. TA2.A1

(1)

Campylobacter jejuni RM1221

(1)

Escherichia coli DH1

(1)

Felis catus

(1)

Geobacillus stearothermophilus

(1)

Methanothermobacter thermautotrophicus

(1)

Paracoccus denitrificans

(1)

Plasmodium falciparum 3D7

(1)

Pyrobaculum aerophilum str. IM2

(1)

Trypanosoma cruzi

(1)

Yarrowia lipolytica

(1)

Molecule name  (39)

Pyruvate kinase PKM

(41)

Pyruvate kinase muscle isozyme

(41)

Threonine-protein kinase PKM2

(41)

Tyrosine-protein kinase PKM2

(41)

F-ATPase gamma subunit

(35)

CTHBP

(32)

Cytosolic thyroid hormone-binding protein

(32)

OIP-3

(32)

Opa-interacting protein 3

(32)

Pyruvate kinase 2/3

(32)

THBP1

(32)

Thyroid hormone-binding protein 1

(32)

Tumor M2-PK

(32)

p58

(32)

Pyruvate kinase

(27)

ATP synthase F(1) complex subunit gamma, mitochondrial

(18)

ATP synthase F1 subunit gamma

(18)

PK

(18)

Pyruvate kinase 1

(14)

ATP synthase subunit gamma, mitochondrial

(13)

PK 1

(8)

Pyruvate kinase PKLR

(6)

Pyruvate kinase isozymes L/R

(6)

R-type/L-type pyruvate kinase

(6)

Red cell/liver pyruvate kinase

(6)

ATP synthase F1 sector gamma subunit

(4)

ATP synthase gamma chain

(4)

PK-1

(4)

Pyruvate kinase I

(4)

Pyruvate kinase 2, putative

(3)

Pyruvate kinase C-terminal domain-containing protein

(2)

Pyruvate kinase PyK1

(2)

cell division cycle protein 19

(2)

ATP synthase subunit gamma

(1)

ATP:pyruvate 2-O-phosphotransferase

(1)

Conserved protein

(1)

Protein glycosylation B

(1)

Uncharacterized protein

(1)

Undecaprenyl-diphosphooligosaccharide--protein glycotransferase

(1)

Molecule type  (1)

Protein

(124)

Gene names  (45)

5565629

(1)

PKM

(41)

PKM2

(33)

OIP3

(32)

PK2

(32)

PK3

(32)

ATP5C

(18)

ATP5C1

(18)

ATP5F1C

(18)

ATP3

(13)

PYK

(13)

ATP3a

(12)

ATP3b

(12)

YBR039W

(12)

YBR0408

(12)

PYK1

(8)

PK1

(6)

PKL

(6)

PKLR

(6)

pyk

(5)

atpG

(4)

pykF

(4)

JW1666

(3)

SAR1776

(3)

Tc00.1047053511281.60

(3)

b1676

(3)

CDC19

(2)

JW3711

(2)

TGRH88_072970

(2)

YAL038W

(2)

b3733

(2)

cgd1_2040

(2)

papC

(2)

pk

(2)

uncG

(2)

AF_0103

(1)

CJE1268

(1)

ECs2383

(1)

MTH_1675

(1)

PAE0819

(1)

PF3D7_0626800

(1)

Pden_3817

(1)

YALI0_F02893g

(1)

Z2704

(1)

pglB

(1)

Interacting Molecules  (43)

ATP synthase F(1) complex catalytic subunit beta, mitochondrial

(18)

ATP synthase F(1) complex subunit alpha, mitochondrial

(18)

ATP synthase subunit alpha, mitochondrial

(13)

ATP synthase subunit beta, mitochondrial

(13)

ATP synthase subunit delta, mitochondrial

(13)

ATP synthase F(1) complex subunit delta, mitochondrial

(11)

ATP synthase F(1) complex subunit epsilon, mitochondrial

(11)

ATP synthase subunit epsilon, mitochondrial

(10)

ATP synthase subunit 9, mitochondrial

(6)

ATP synthase epsilon chain

(4)

ATP synthase subunit a

(4)

ATPase inhibitor, mitochondrial

(4)

ATP synthase protein 8

(3)

ATP synthase subunit 4, mitochondrial

(3)

ATP synthase subunit 5, mitochondrial

(3)

ATP synthase subunit J, mitochondrial

(3)

ATP synthase subunit alpha

(3)

ATP synthase subunit beta

(3)

ATP synthase subunit d, mitochondrial

(3)

ATP synthase subunit f, mitochondrial

(3)

ATP synthase catalytic sector F1 epsilon subunit

(2)

ATP synthase subunit H, mitochondrial

(2)

AATP synthase subunit g

(1)

ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL

(1)

ATP synthase F(0) complex subunit C1, mitochondrial

(1)

ATP synthase peripheral stalk subunit F6, mitochondrial

(1)

ATP synthase peripheral stalk subunit OSCP, mitochondrial

(1)

ATP synthase peripheral stalk subunit b, mitochondrial

(1)

ATP synthase peripheral stalk subunit d, mitochondrial

(1)

ATP synthase subunit K, mitochondrial

(1)

ATP synthase subunit c

(1)

ATP synthase subunit delta

(1)

ATP synthase subunit e, mitochondrial

(1)

ATP synthase subunit h

(1)

Chain A

(1)

Chain B

(1)

Chain C

(1)

Chain V

(1)

Chain W

(1)

Chain Y

(1)

DUF1476 domain-containing protein

(1)

F(1)-ATPase inhibitor IF(1), mitochondrial

(1)

Pyruvate kinase PKM

(1)

Interacting ligands  (62)

K : POTASSIUM ION

(42)

MG : MAGNESIUM ION

(28)

FBP : 1,6-di-O-phosphono-beta-D-fructofuranose

(25)

GOL : GLYCEROL

(23)

SO4 : SULFATE ION

(16)

PO4 : PHOSPHATE ION

(14)

MN : MANGANESE (II) ION

(13)

OXL : OXALATE ION

(13)

PYR : PYRUVIC ACID

(9)

FDP : 2,6-di-O-phosphono-beta-D-fructofuranose

(8)

PGA : 2-PHOSPHOGLYCOLIC ACID

(6)

ATP : ADENOSINE-5'-TRIPHOSPHATE

(5)

EDO : 1,2-ETHANEDIOL

(5)

NA : SODIUM ION

(4)

PTK : pyrene-1,3,6,8-tetrasulfonic acid

(4)

SER : SERINE

(4)

ACT : ACETATE ION

(2)

ADN : ADENOSINE

(2)

FLC : CITRATE ANION

(2)

FMN : FLAVIN MONONUCLEOTIDE

(2)

PEG : DI(HYDROXYETHYL)ETHER

(2)

PHE : PHENYLALANINE

(2)

PRO : PROLINE

(2)

QV7 : 3-hydroxy-4-[(E)-{2-sulfo-4-[(E)-(4-sulfophenyl)diazenyl]phenyl}diazenyl]naphthalene-2,7-disulfonic acid

(2)

TLA : L(+)-TARTARIC ACID

(2)

07T : 6-(3-aminobenzyl)-4-methyl-2-methylsulfinyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

(1)

09C : (3S,5R)-3,5-bis(6-bromo-1H-indol-3-yl)piperazin-2-one

(1)

1OX : 2-(1H-benzimidazol-1-ylmethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

(1)

1PE : PENTAETHYLENE GLYCOL

(1)

3SZ : 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline

(1)

7XX : 4-[2,3-bis(chloranyl)phenyl]carbonyl-1-methyl-pyrrole-2-carboxamide

(1)

7Y0 : 4-[2,3-bis(chloranyl)phenyl]carbonyl-N-[2-[[4-[2,3-bis(chloranyl)phenyl]carbonyl-1-methyl-pyrrol-2-yl]carbonylamino]ethyl]-1-methyl-pyrrole-2-carboxamide

(1)

ADP : ADENOSINE-5'-DIPHOSPHATE

(1)

AKG : 2-OXOGLUTARIC ACID

(1)

ALA : ALANINE

(1)

B3P : 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL

(1)

CA : CALCIUM ION

(1)

CIT : CITRIC ACID

(1)

CL : CHLORIDE ION

(1)

D8G : 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

(1)

DYY : 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine

(1)

DZG : 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine

(1)

ETE : 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL

(1)

I30 : N'-[(1E)-1-(1H-benzimidazol-2-yl)ethylidene]-5-bromo-2-hydroxybenzohydrazide

(1)

LSA : 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE

(1)

MLI : MALONATE ION

(1)

MLT : D-MALATE

(1)

NZT : N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]carbonyl}phenyl)quinoline-8-sulfonamide

(1)

OXD : OXALIC ACID

(1)

PEP : PHOSPHOENOLPYRUVATE

(1)

PEQ : L-PHOSPHOLACTATE

(1)

PG4 : TETRAETHYLENE GLYCOL

(1)

PIT : PICEATANNOL

(1)

QUE : 3,5,7,3',4'-PENTAHYDROXYFLAVONE

(1)

QV6 : 3-({4-[(2,4-dimethyl-5-sulfophenyl)amino]-9,10-dioxo-9,10-dihydroanthracen-1-yl}amino)-2,4,6-trimethylbenzenesulfonic acid

(1)

QV8 : 9,10-dioxo-4-(phenylamino)-9,10-dihydroanthracene-2-sulfonic acid

(1)

S62 : 1,3-benzothiazole-2,5-disulfonic acid

(1)

SCN : THIOCYANATE ION

(1)

STL : RESVERATROL

(1)

SVR : 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID

(1)

TRP : TRYPTOPHAN

(1)

UNL : Unknown ligand

(1)

EC number / name  (6)

2.7.1.40 : Pyruvate kinase

(86)

2.7.10.2 : Non-specific protein-tyrosine kinase

(41)

2.7.11.1 : Non-specific serine/threonine protein kinase

(41)

3.6.1.34 :

(11)

3.6.3.14 :

(10)

2.4.99.19 : Undecaprenyl-diphosphooligosaccharide--protein glycotransferase

(1)

Biological function  (21)

ATP binding

(89)

nucleotide binding

(88)

metal ion binding

(87)

catalytic activity

(86)

kinase activity

(86)

magnesium ion binding

(86)

potassium ion binding

(86)

pyruvate kinase activity

(86)

transferase activity

(86)

protein binding

(68)

mRNA binding

(41)

protein tyrosine kinase activity

(41)

proton-transporting ATP synthase activity, rotational mechanism

(35)

MHC class II protein complex binding

(32)

RNA binding

(32)

cadherin binding

(32)

monosaccharide binding

(6)

transferase activity, transferring phosphorus-containing groups

(4)

identical protein binding

(3)

proton-transporting ATPase activity, rotational mechanism

(3)

oxidoreductase activity

(2)

Biological process  (25)

glycolytic process

(86)

positive regulation of cytoplasmic translation

(41)

positive regulation of sprouting angiogenesis

(41)

regulation of translation

(41)

cellular response to insulin stimulus

(39)

proton motive force-driven ATP synthesis

(35)

canonical glycolysis

(32)

programmed cell death

(32)

ATP biosynthetic process

(23)

monoatomic ion transport

(23)

proton transmembrane transport

(23)

proton motive force-driven mitochondrial ATP synthesis

(18)

cellular response to epinephrine stimulus

(6)

pyruvate biosynthetic process

(6)

response to ATP

(6)

response to cAMP

(6)

response to glucose

(6)

response to hypoxia

(6)

response to metal ion

(6)

response to nutrient

(6)

phosphorylation

(4)

proton motive force-driven plasma membrane ATP synthesis

(3)

response to heat

(3)

monocarboxylic acid metabolic process

(2)

protein homotetramerization

(1)

Biological cell component  (20)

cytoplasm

(54)

mitochondrion

(52)

cytosol

(41)

nucleus

(41)

rough endoplasmic reticulum

(41)

extracellular exosome

(38)

proton-transporting ATP synthase complex

(35)

cilium

(32)

collagen-containing extracellular matrix

(32)

extracellular region

(32)

extracellular vesicle

(32)

ficolin-1-rich granule lumen

(32)

intracellular membrane-bounded organelle

(32)

secretory granule lumen

(32)

vesicle

(32)

membrane

(26)

mitochondrial inner membrane

(20)

plasma membrane

(5)

pyruvate kinase complex

(3)

obsolete proton-transporting ATP synthase complex, catalytic core F(1)

(1)

SCOP fold  (4)

Pyruvate kinase C-terminal domain-like

(24)

PK beta-barrel domain-like

(16)

TIM beta/alpha-barrel

(16)

ATP synthase

(4)

SCOP family  (6)

Pyruvate kinase

(16)

Pyruvate kinase beta-barrel domain

(16)

Pyruvate kinase, C-terminal domain

(16)

ATP synthase (F1-ATPase), gamma subunit

(6)

ATP synthase

(4)

MTH1675-like

(2)

CATH class  (3)

Alpha Beta

(124)

Mainly Beta

(68)

Mainly Alpha

(35)

CATH topology  (5)

Pyruvate Kinase; Chain: A, domain 1

(124)

TIM Barrel

(86)

M1 Pyruvate Kinase; Domain 3

(68)

Helix Hairpins

(35)

Glucose Oxidase; domain 1

(4)

Pfam accession / name  (6)

PF02887 : PK_C

(88)

PF00224 : PK

(86)

PF00231 : ATP-synt

(35)

PF00391 : PEP-utilizers

(4)

PF18527 : STT3_PglB_C

(1)

PF21436 : STT3-PglB_core

(1)

Diffraction protocol  (2)

Single wavelength

(113)

MAD

(3)

Diffraction radiation source type  (2)

Synchrotron

(105)

Rotating anode

(14)

Diffraction source  (57)

DIAMOND BEAMLINE I03

(13)

ESRF BEAMLINE ID14-2

(7)

CLSI BEAMLINE 08ID-1

(6)

DIAMOND BEAMLINE I24

(5)

ESRF BEAMLINE ID23-1

(5)

SSRF BEAMLINE BL17U

(5)

APS BEAMLINE 23-ID-B

(4)

DIAMOND BEAMLINE I04-1

(4)

APS BEAMLINE 19-ID

(3)

APS BEAMLINE 22-ID

(3)

DIAMOND BEAMLINE I04

(3)

ESRF BEAMLINE ID14-4

(3)

RIGAKU RUH2R

(3)

SLS BEAMLINE X06SA

(3)

SRS BEAMLINE PX9.6

(3)

APS BEAMLINE 24-ID-C

(2)

ELETTRA BEAMLINE 5.2R

(2)

ESRF BEAMLINE ID23-2

(2)

ESRF BEAMLINE ID29

(2)

MACSCIENCE

(2)

NSLS BEAMLINE X25

(2)

NSLS BEAMLINE X6A

(2)

RIGAKU FR-E

(2)

RIGAKU FR-E DW

(2)

SSRL BEAMLINE BL7-1

(2)

ALS BEAMLINE 4.2.2

(1)

ALS BEAMLINE 8.3.1

(1)

APS BEAMLINE 14-BM-C

(1)

APS BEAMLINE 14-ID-B

(1)

APS BEAMLINE 19-BM

(1)

APS BEAMLINE 23-ID-D

(1)

APS BEAMLINE 5ID-B

(1)

AUSTRALIAN SYNCHROTRON BEAMLINE MX1

(1)

CAMD BEAMLINE GCPCC

(1)

CHESS BEAMLINE F1

(1)

DIAMOND BEAMLINE I02

(1)

EMBL/DESY, HAMBURG BEAMLINE BW7A

(1)

EMBL/DESY, HAMBURG BEAMLINE X11

(1)

ESRF

(1)

ESRF BEAMLINE BM14

(1)

ESRF BEAMLINE ID14-1

(1)

ESRF BEAMLINE ID14-3

(1)

NSRRC BEAMLINE BL13B1

(1)

NSRRC BEAMLINE BL13C1

(1)

PHOTON FACTORY BEAMLINE AR-NW12A

(1)

PHOTON FACTORY BEAMLINE BL-17A

(1)

RIGAKU

(1)

RIGAKU FR-E SUPERBRIGHT

(1)

RIGAKU FR-E+ DW

(1)

RIGAKU MICROMAX-007

(1)

RIGAKU RU200

(1)

SLS BEAMLINE X10SA

(1)

SPRING-8 BEAMLINE BL38B1

(1)

SPRING-8 BEAMLINE BL44XU

(1)

SRS BEAMLINE PX14.2

(1)

SRS BEAMLINE PX7.2

(1)

SSRL BEAMLINE BL11-1

(1)

Synchrotron site  (18)

Diamond

(26)

ESRF

(23)

APS

(17)

CLSI

(6)

SRS

(5)

SSRF

(5)

SLS

(4)

NSLS

(3)

SSRL

(3)

ALS

(2)

ELETTRA

(2)

EMBL/DESY, Hamburg

(2)

NSRRC

(2)

Photon Factory

(2)

Australian Synchrotron

(1)

CAMD

(1)

CHESS

(1)

SPring-8

(1)

Diffraction detector type  (5)

CCD

(76)

Image plate

(19)

Pixel

(16)

CMOS

(1)

Film

(1)

Refinement software  (8)

REFMAC

(86)

PHENIX

(18)

CNS

(10)

TNT

(5)

X-PLOR

(4)

BUSTER

(2)

PROLSQ

(1)

prodrg

(1)

EM microscope model  (2)

FEI POLARA 300

(2)

FEI TITAN KRIOS

(1)

EM detector name  (2)

GATAN K2 SUMMIT (4k x 4k)

(2)

GATAN K2 QUANTUM (4k x 4k)

(1)

Representative Structures

100%

95%

90%

70%

50%

40%

30%