Entry status  (1)

REL

(6)

Experimental methods  (1)

X-ray diffraction

(6)

Authors  (44)

Chen X

(3)

Becker S

(2)

Darnell JE

(2)

Darnell Jr JE

(2)

Mao X

(2)

McMurray JS

(2)

Ren Z

(2)

Bui TT

(1)

Collie GW

(1)

Demeler B

(1)

Drake AF

(1)

Groner B

(1)

Husby J

(1)

Jeruzalmi D

(1)

Klumpp K

(1)

Krishnaraj R

(1)

Kuriyan J

(1)

Mandal PK

(1)

Mertens C

(1)

Muller CW

(1)

Müller CW

(1)

Neculai AM

(1)

Neculai D

(1)

Neidle S

(1)

Nkansah E

(1)

Palmer J

(1)

Parker GN

(1)

Parkinson GN

(1)

Pastorello MA

(1)

Pfitzner E

(1)

Qin J

(1)

Rahman KM

(1)

Romanowshi MJ

(1)

Romanowski MJ

(1)

Shah R

(1)

Sondermann H

(1)

Straub K

(1)

Thurston DE

(1)

Verrier S

(1)

Vinkemeier U

(1)

Wang W

(1)

Wilderspin AF

(1)

Zhao Y

(1)

Zinzalla G

(1)

Homo / hetero assembly  (2)

hetero

(4)

homo

(2)

Assembly composition  (3)

DNA/protein complex

(3)

protein structure

(2)

protein/protein complex

(1)

Assembly polymer count  (3)

tetramer

(3)

dimer

(2)

monomer

(1)

Resolution distribution

2.0 - 2.5

(1)

2.5 - 3

(3)

3.0 - 3.5

(2)

Release year distribution

1995 - 2000

(2)

2000 - 2005

(2)

2005 - 2010

(3)

2010 - 2015

(1)

Journal  (6)

Biochem Biophys Res Commun

(1)

Cell

(1)

FEBS Lett

(1)

J Biol Chem

(1)

Mol Cell

(1)

Nature

(1)

Organism superkingdom  (1)

Eukaryota

(6)

Organism name  (2)

Mus musculus

(4)

Homo sapiens

(2)

Molecule name  (6)

Acute-phase response factor

(3)

Signal transducer and activator of transcription 3

(3)

Signal transducer and activator of transcription 1-alpha/beta

(2)

Transcription factor ISGF-3 components p91/p84

(2)

Mammary gland factor

(1)

Signal transducer and activator of transcription 5A

(1)

Molecule type  (1)

Protein

(6)

Gene names  (6)

Aprf

(3)

Stat3

(3)

STAT1

(2)

Mgf

(1)

Mpf

(1)

Stat5a

(1)

Interacting Molecules  (4)

DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3')

(2)

5-residue peptide

(1)

DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3')

(1)

DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3')

(1)

Interacting ligands  (1)

AU : GOLD ION

(1)

Biological function  (22)

DNA binding

(6)

DNA-binding transcription factor activity

(6)

CCR5 chemokine receptor binding

(1)

DNA-binding transcription factor activity, RNA polymerase II-specific

(1)

RNA polymerase II cis-regulatory region sequence-specific DNA binding

(1)

RNA polymerase II core promoter sequence-specific DNA binding

(1)

RNA polymerase II transcription regulatory region sequence-specific DNA binding

(1)

cadherin binding

(1)

double-stranded DNA binding

(1)

enzyme binding

(1)

histone acetyltransferase binding

(1)

histone binding

(1)

identical protein binding

(1)

promoter-specific chromatin binding

(1)

protein binding

(1)

protein homodimerization activity

(1)

protein phosphatase 2A binding

(1)

sequence-specific DNA binding

(1)

transcription coactivator binding

(1)

transcription corepressor binding

(1)

tumor necrosis factor receptor binding

(1)

ubiquitin-like protein ligase binding

(1)

Biological process  (50)

regulation of DNA-templated transcription

(6)

signal transduction

(6)

blood circulation

(1)

cell surface receptor signaling pathway via JAK-STAT

(1)

cell surface receptor signaling pathway via STAT

(1)

cellular response to cytokine stimulus

(1)

cellular response to insulin stimulus

(1)

cellular response to interferon-beta

(1)

cellular response to type II interferon

(1)

cytokine-mediated signaling pathway

(1)

defense response

(1)

defense response to virus

(1)

endothelial cell migration

(1)

interleukin-27-mediated signaling pathway

(1)

interleukin-7-mediated signaling pathway

(1)

interleukin-9-mediated signaling pathway

(1)

metanephric mesenchymal cell differentiation

(1)

metanephric mesenchymal cell proliferation involved in metanephros development

(1)

negative regulation by virus of viral protein levels in host cell

(1)

negative regulation of angiogenesis

(1)

negative regulation of canonical NF-kappaB signal transduction

(1)

negative regulation of endothelial cell proliferation

(1)

negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

(1)

negative regulation of metanephric nephron tubule epithelial cell differentiation

(1)

negative regulation of transcription by RNA polymerase II

(1)

positive regulation of DNA-templated transcription

(1)

positive regulation of cell population proliferation

(1)

positive regulation of defense response to virus by host

(1)

positive regulation of erythrocyte differentiation

(1)

positive regulation of interferon-alpha production

(1)

positive regulation of mesenchymal cell proliferation

(1)

positive regulation of nitric oxide biosynthetic process

(1)

positive regulation of smooth muscle cell proliferation

(1)

positive regulation of transcription by RNA polymerase II

(1)

regulation of apoptotic process

(1)

regulation of cell population proliferation

(1)

regulation of transcription by RNA polymerase II

(1)

renal tubule development

(1)

response to cAMP

(1)

response to cytokine

(1)

response to hydrogen peroxide

(1)

response to interferon-beta

(1)

response to mechanical stimulus

(1)

response to nutrient

(1)

response to peptide hormone

(1)

response to type II interferon

(1)

response to xenobiotic stimulus

(1)

tumor necrosis factor-mediated signaling pathway

(1)

type I interferon-mediated signaling pathway

(1)

type II interferon-mediated signaling pathway

(1)

Biological cell component  (12)

ISGF3 complex

(1)

RNA polymerase II transcription regulator complex

(1)

axon

(1)

chromatin

(1)

cytoplasm

(1)

cytosol

(1)

dendrite

(1)

nucleolus

(1)

nucleoplasm

(1)

nucleus

(1)

perinuclear region of cytoplasm

(1)

protein-containing complex

(1)

SCOP fold  (3)

Common fold of diphtheria toxin/transcription factors/cytochrome f

(2)

SH2-like

(2)

STAT-like

(2)

SCOP family  (3)

SH2 domain

(2)

STAT

(2)

STAT DNA-binding domain

(2)

CATH class  (3)

Alpha Beta

(6)

Mainly Alpha

(6)

Mainly Beta

(6)

CATH topology  (5)

Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2

(6)

Immunoglobulin-like

(6)

Recoverin; domain 1

(6)

SHC Adaptor Protein

(6)

Transcription Factor, Stat-4

(1)

Pfam accession / name  (5)

PF00017 : SH2

(6)

PF01017 : STAT_alpha

(6)

PF02864 : STAT_bind

(6)

PF21354 : STAT_linker

(6)

PF02865 : STAT_int

(1)

Diffraction protocol  (1)

Single wavelength

(6)

Diffraction radiation source type  (1)

Synchrotron

(6)

Diffraction source  (6)

ALS BEAMLINE 8.2.2

(1)

ALS BEAMLINE 8.3.1

(1)

BESSY BEAMLINE 14.2

(1)

CHESS BEAMLINE A1

(1)

DIAMOND BEAMLINE I04-1

(1)

ESRF BEAMLINE ID2

(1)

Synchrotron site  (5)

ALS

(2)

BESSY

(1)

CHESS

(1)

Diamond

(1)

ESRF

(1)

Diffraction detector type  (4)

CCD

(2)

Image plate

(2)

Area detector

(1)

Pixel

(1)

Refinement software  (3)

CNS

(3)

REFMAC

(2)

X-PLOR

(1)

Representative Structures

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