All structure family : Telomere repeat-binding factor, dimerisation domain
 
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Entry Information
Entry status  (1)
REL
(12)
 
Experimental methods  (1)
X-ray diffraction
(12)
 
Authors  (72)
Chen Y
(8)
Lei M
(8)
Yang Y
(5)
de Lange T
(5)
Baciu P
(3)
Donigian JR
(3)
van Overbeek M
(3)
Chang S
(2)
Chapman L
(2)
Fairall L
(2)
Liu Y
(2)
Moss H
(2)
Rhodes D
(2)
Wu J
(2)
Broton C
(1)
Buisson R
(1)
Chen X
(1)
Diehl JA
(1)
Fujiwara Y
(1)
Gaullier G
(1)
Gilson E
(1)
Giraud-Panis M-J
(1)
Giraud-Panis MJ
(1)
Gu P
(1)
Guimaraes B
(1)
Guimaraes BG
(1)
Guimarães BG
(1)
Guo T
(1)
Horvath K
(1)
Hu C
(1)
Huang C
(1)
Le Bihan YV
(1)
Le Du M-H
(1)
Le Du MH
(1)
Liu C
(1)
Liu L
(1)
Liu X
(1)
Liu XD
(1)
Long J
(1)
Lu J
(1)
Lue NF
(1)
Messaoud W
(1)
Miron S
(1)
Nandakumar J
(1)
Pendlebury DF
(1)
Pisano S
(1)
Rai R
(1)
Roblin P
(1)
Sarkar J
(1)
Shi S
(1)
Shibuya H
(1)
Smith EM
(1)
Sun H
(1)
Tellier-Lebegue C
(1)
Tellier-Lebègue C
(1)
Tesmer VM
(1)
Thai R
(1)
Wan B
(1)
Wan K
(1)
Wang S
(1)
Wang W
(1)
Watanabe Y
(1)
Wu L
(1)
Yang CY
(1)
Yang X
(1)
Yang XM
(1)
Yang YT
(1)
Yin J
(1)
Yu EY
(1)
Zeng Z
(1)
Zeng ZX
(1)
Zhang Y
(1)
 
Homo / hetero assembly  (2)
hetero
(10)
homo
(2)
 
Assembly composition  (2)
protein/protein complex
(10)
protein structure
(2)
 
Assembly polymer count  (2)
dimer
(8)
tetramer
(4)
 
Resolution distribution
1.5 - 2
(1)
2.0 - 2.5
(9)
2.5 - 3
(2)
 
Release year distribution
2000 - 2005
(2)
2005 - 2010
(4)
2010 - 2015
(2)
2015 - 2020
(5)
 
Journal  (7)
Mol Cell
(3)
Science
(3)
Nat Struct Mol Biol
(2)
ACS Med Chem Lett
(1)
Cell Rep
(1)
Dev Cell
(1)
Nucleic Acids Res
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(12)
 
Organism name  (1)
Homo sapiens
(12)
 
Molecule name  (7)
TTAGGG repeat-binding factor 2
(7)
Telomeric DNA-binding protein
(7)
Telomeric repeat-binding factor 2
(7)
NIMA-interacting protein 2
(5)
TTAGGG repeat-binding factor 1
(5)
Telomeric protein Pin2/TRF1
(5)
Telomeric repeat-binding factor 1
(5)
 
Molecule type  (1)
Protein
(12)
 
Gene names  (8)
TERF2
(7)
TRBF2
(7)
TRF2
(7)
PIN2
(5)
TERF1
(5)
TRBF1
(5)
TRF
(5)
TRF1
(5)
 
Interacting Molecules  (8)
TERF1-interacting nuclear factor 2
(2)
Telomere repeats-binding bouquet formation protein 1
(2)
3FB-PHE-B8R-LEU-5XU-PRO
(1)
5' exonuclease Apollo
(1)
F-box only protein 4
(1)
Nibrin
(1)
Structure-specific endonuclease subunit SLX4
(1)
Telomeric repeat-binding factor 2-interacting protein 1
(1)
 
Interacting ligands  (1)
GOL : GLYCEROL
(1)
 
Function and Biology
Biological function  (2)
protein homodimerization activity
(12)
telomeric DNA binding
(12)
 
Biological process  (2)
protection from non-homologous end joining at telomere
(7)
telomere maintenance
(7)
 
Biological cell component  (2)
chromosome, telomeric region
(7)
nucleus
(7)
 
Sequence and Structure classification
SCOP fold  (1)
Telomeric repeat binding factor (TRF) dimerisation domain
(5)
 
SCOP family  (1)
Telomeric repeat binding factor (TRF) dimerisation domain
(5)
 
CATH class  (1)
Mainly Alpha
(12)
 
CATH topology  (1)
Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
(12)
 
Pfam accession / name  (1)
PF08558 : TRF
(12)
 
Experimental Information
Diffraction protocol  (2)
Single wavelength
(11)
MAD
(1)
 
Diffraction radiation source type  (1)
Synchrotron
(12)
 
Diffraction source  (7)
APS BEAMLINE 21-ID-F
(4)
APS BEAMLINE 21-ID-D
(2)
SRS BEAMLINE PX9.6
(2)
APS BEAMLINE 23-ID-B
(1)
APS BEAMLINE 23-ID-D
(1)
SOLEIL BEAMLINE PROXIMA 1
(1)
SSRF BEAMLINE BL18U1
(1)
 
Synchrotron site  (4)
APS
(8)
SRS
(2)
SOLEIL
(1)
SSRF
(1)
 
Diffraction detector type  (3)
CCD
(10)
Image plate
(1)
Pixel
(1)
 
Refinement software  (4)
CNS
(6)
PHENIX
(4)
REFMAC
(2)
BUSTER
(1)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 12
Entries 1 to 10 of 12
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Structure of the TRF1-TERB1 interface
Nandakumar J, Pendlebury DF, Smith EM, Tesmer VM
Nat Struct Mol Biol (2017) [PMID: 29083414  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Telomeric repeat-binding factor 1 and Telomere repeats-binding bouquet formation protein 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-156975 (Preferred)   search this ID
PDBe-KB: P54274    Q8NA31   
X-ray diffraction
2.1Å resolution
Released: 18 Oct 2017
Model geometry
Fit model/data
5wir
5wir
5wir
Crystal structure of TRF2 TRFH in complex with an NBS1 peptide
Hu C, Chen Y, Lei M
Mol Cell (2017) [PMID: 28216226  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Nibrin and Telomeric repeat-binding factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-130214 (Preferred)   search this ID
PDBe-KB: Q15554    O60934   
X-ray diffraction
3Å resolution
Released: 8 Mar 2017
Model geometry
Fit model/data
5wqd
5wqd
5wqd
Crystal structure of TRF1 and TERB1
Long J, Huang C, Wu J, Lei M
Nat Struct Mol Biol (2017) [PMID: 29083416  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: Telomeric repeat-binding factor 1 and Telomere repeats-binding bouquet formation protein 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-156975 (Preferred)   search this ID
PDBe-KB: P54274    Q8NA31   
X-ray diffraction
2.1Å resolution
Released: 1 Nov 2017
Model geometry
Fit model/data
5xup
5xup
5xup
Crystal structure of the compound 34 in a complex with TRF2
Chen Y, Yang Y, Lei M
ACS Med Chem Lett (2018) [PMID: 29795768  ]
Assembly composition: protein/protein complex
Modified residues: 3FB    B8R    B8R    3FB   
Assembly name: Telomeric repeat-binding factor 2 and peptide (Preferred)   search this complex
PDBe complex ID: PDB-CPX-166915 (Preferred)   search this ID
PDBe-KB: Q15554   
X-ray diffraction
2.05Å resolution
Released: 13 Feb 2019
Model geometry
Fit model/data
6j67
6j67
6j67
Structure of TRF2/RAP1 secondary interaction binding site
Miron S, Guimaraes B, Gaullier G, Giraud-Panis M-J, Gilson E, Le Du M-H
Nucleic Acids Res (2016) [PMID: 26748096  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    GOL    MG   
Assembly name: Telomeric repeat-binding factor 2-interacting protein 1 and Telomeric repeat-binding factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172323 (Preferred)   search this ID
PDBe-KB: Q15554    Q9NYB0   
X-ray diffraction
2.4405Å resolution
Released: 10 Feb 2016
Model geometry
Fit model/data
4rqi
4rqi
4rqi
Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2
Wan B, Chen Y, Wu J, Liu Y, Lei M
Cell Rep (2013) [PMID: 24012755  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: SLX4-TERF2 complex (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172321 (Preferred)   search this ID
PDBe-KB: Q15554    Q8IY92   
X-ray diffraction
2.05Å resolution
Released: 25 Sep 2013
Model geometry
Fit model/data
4m7c
4m7c
4m7c
X-ray Crystal structure of TRF1 and Fbx4 complex
Zeng ZX, Wang W, Yang YT, Chen Y, Yang XM, Diehl JA, Liu XD, Lei M
Dev Cell (2010) [PMID: 20159592  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Modified residues: MSE    MSE   
Assembly name: F-box only protein 4 and Telomeric repeat-binding factor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-156972 (Preferred)   search this ID
PDBe-KB: P54274    Q9UKT5   
X-ray diffraction
2.4Å resolution
Released: 9 Mar 2010
Model geometry
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3l82
3l82
3l82
Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex
Chen Y, Yang Y, van Overbeek M, Donigian JR, Baciu P, de Lange T, Lei M
Science (2008) [PMID: 18202258  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Assembly name: TERF1-interacting nuclear factor 2 and Telomeric repeat-binding factor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-156971 (Preferred)   search this ID
PDBe-KB: P54274    Q9BSI4   
X-ray diffraction
2Å resolution
Released: 19 Feb 2008
Model geometry
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3bqo
3bqo
3bqo
Dimeristion domain from human TRF2
Chapman L, Fairall L, Rhodes D
Mol Cell (2001) [PMID: 11545737  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: MG    MG   
Assembly name: Telomeric repeat-binding factor 2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-172320 (Preferred)   search this ID
PDBe-KB: Q15554   
X-ray diffraction
2.2Å resolution
Released: 5 Sep 2001
Model geometry
Fit model/data
Data not analysed
1h6p
1h6p
1h6p
Dimerisation domain from human TRF1
Fairall L, Chapman L, Rhodes D
Mol Cell (2001) [PMID: 11545737  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Assembly name: Telomeric repeat-binding factor 1 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-156973 (Preferred)   search this ID
PDBe-KB: P54274   
X-ray diffraction
2.9Å resolution
Released: 5 Sep 2001
Model geometry
Fit model/data
1h6o
1h6o
1h6o
Entries 1 to 10 of 12
Entries 1 to 10 of 12