All structure family : ubp-family deubiquitinating enzyme fold
 
Filter by :
Latest PDB release
Entries released this week  (1)
revised
(1)
 
Entry Information
Entry status  (1)
REL
(40)
 
Experimental methods  (1)
X-ray diffraction
(40)
 
Authors  (303)
Rouge L
(9)
Rougé L
(9)
Hearn BR
(7)
Zhang Y
(7)
Shi W
(6)
Wang L
(6)
Zhou T
(6)
Bashore C
(5)
Becker MM
(5)
Denison MR
(5)
Dueber EC
(5)
Graham BS
(5)
Joyce MG
(5)
Kanekiyo M
(5)
Kong WP
(5)
Kwong PD
(5)
Li Y
(5)
Mascola JR
(5)
Modjarrad K
(5)
Ozen A
(5)
Shi Y
(5)
Skelton NJ
(5)
Wang X
(5)
Özen A
(5)
Di Lello P
(4)
Gao GF
(4)
Liu X
(4)
Lu G
(4)
Maurer T
(4)
Murray JM
(4)
Qi J
(4)
Wang N
(4)
Wang Q
(4)
Yan J
(4)
Anderson KC
(3)
Arkoudis E
(3)
Bagci U
(3)
Bainbridge TW
(3)
Barker O
(3)
Blake RA
(3)
Buhrlage SJ
(3)
Cassidy E
(3)
Chauhan D
(3)
Chen X
(3)
Cohen F
(3)
Das D
(3)
Dhe-Paganon S
(3)
Dossang A
(3)
Drummond J
(3)
Engen JR
(3)
Ernst JA
(3)
Flasz J
(3)
Freeman M
(3)
Gavory G
(3)
Gu W
(3)
Harrison T
(3)
Helm M
(3)
Helm MD
(3)
Hensley L
(3)
Hu M
(3)
Hu W
(3)
Hughes C
(3)
Iacob RE
(3)
Jahrling P
(3)
Jiang L
(3)
Johnson JC
(3)
Kategaya L
(3)
Kleinheinz T
(3)
Lamberto I
(3)
Lees CR
(3)
Leung K
(3)
Li M
(3)
Li W
(3)
McClelland K
(3)
Miel H
(3)
Mikhailova T
(3)
Mollura DJ
(3)
Murray J
(3)
Ndubaku C
(3)
O'Dowd C
(3)
O'Dowd CR
(3)
Odrzywol E
(3)
Olinger G
(3)
Page N
(3)
Pastor R
(3)
Rao SS
(3)
Schauer NJ
(3)
Seo HS
(3)
Shi X
(3)
Solomon J
(3)
Subbarao K
(3)
Todd JP
(3)
Tsui V
(3)
Vogel L
(3)
Wang D
(3)
Weisberg EL
(3)
Wertz IE
(3)
Yang ZY
(3)
Yassine HM
(3)
Yuan Y
(3)
 
More...
 
Homo / hetero assembly  (2)
hetero
(20)
homo
(19)
 
Assembly composition  (2)
protein/protein complex
(20)
protein structure
(19)
 
Assembly polymer count  (4)
monomer
(16)
dimer
(10)
trimer
(10)
tetramer
(3)
 
Resolution distribution
1.0 - 1.5
(2)
1.5 - 2
(4)
2.0 - 2.5
(16)
2.5 - 3
(10)
3.0 - 3.5
(8)
 
Release year distribution
2000 - 2005
(2)
2005 - 2010
(4)
2010 - 2015
(13)
2015 - 2020
(27)
 
Journal  (17)
Structure
(7)
Nature
(6)
Nat Commun
(4)
Cell Chem Biol
(3)
J Virol
(3)
Acta Crystallogr F Struct Biol Commun
(2)
Cell
(2)
Cell Res
(2)
EMBO J
(2)
Nat Chem Biol
(2)
ACS Med Chem Lett
(1)
Cell Host Microbe
(1)
Cell Rep
(1)
J Infect Dis
(1)
J Med Chem
(1)
PLoS Biol
(1)
Sci Rep
(1)
 
Macromolecules
Organism superkingdom  (2)
Eukaryota
(25)
Viruses
(15)
 
Organism name  (7)
Homo sapiens
(22)
Middle East respiratory syndrome-related coronavirus
(6)
Betacoronavirus England 1
(5)
Naja kaouthia
(3)
Human betacoronavirus 2c EMC/2012
(2)
Human betacoronavirus 2c Jordan-N3/2012
(1)
Tylonycteris bat coronavirus HKU4
(1)
 
Molecule name  (20)
Deubiquitinating enzyme 7
(22)
Herpesvirus-associated ubiquitin-specific protease
(22)
Ubiquitin carboxyl-terminal hydrolase 7
(22)
Ubiquitin thioesterase 7
(22)
Ubiquitin-specific-processing protease 7
(22)
E2
(15)
Peplomer protein
(15)
S glycoprotein
(15)
Spike glycoprotein
(15)
Spike protein S1
(15)
Spike protein S2
(15)
Spike protein S2'
(15)
S protein
(6)
CVF
(3)
CVFk
(3)
Cobra venom factor
(3)
Cobra venom factor alpha chain
(3)
Cobra venom factor beta chain
(3)
Cobra venom factor gamma chain
(3)
Complement C3 homolog
(3)
 
Molecule type  (1)
Protein
(40)
 
Gene names  (5)
2
(1)
3
(8)
HAUSP
(22)
USP7
(22)
S
(15)
 
Interacting Molecules  (22)
Ubiquitin
(6)
Cobra venom factor alpha chain
(3)
Cobra venom factor gamma chain
(3)
Complement factor B
(2)
D12 Fab Heavy chain
(2)
Dipeptidyl peptidase 4
(2)
4C2 heavy chain
(1)
4C2 light chain
(1)
Antibody CDC2-C2 heavy chain
(1)
Antibody CDC2-C2 light chain
(1)
D12 Fab Light chain
(1)
D12 Fab light chain
(1)
Heavy chain
(1)
Heavy chain of neutralizing antibody m336
(1)
JC57-14 Heavy chain
(1)
JC57-14 Light chain
(1)
Light chain
(1)
Light chain of neutralizing antibody m336
(1)
MCA1 heavy chain
(1)
MCA1 light chain
(1)
fab Heavy Chain
(1)
fab Light Chain
(1)
 
Interacting ligands  (27)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(15)
GOL : GLYCEROL
(8)
SO4 : SULFATE ION
(3)
BMA : beta-D-mannopyranose
(2)
BR : BROMIDE ION
(2)
EDO : 1,2-ETHANEDIOL
(2)
MG : MAGNESIUM ION
(2)
PO4 : PHOSPHATE ION
(2)
8JM : 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl]phenol
(1)
8JP : 6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl[3,3'-bipyridine]-6-carboxamide
(1)
8QQ : 3-[4-(aminomethyl)phenyl]-2-methyl-6-[[4-oxidanyl-1-[(3~{R})-4,4,4-tris(fluoranyl)-3-phenyl-butanoyl]piperidin-4-yl]methyl]pyrazolo[4,3-d]pyrimidin-7-one
(1)
8RN : 7-bromanyl-3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]thieno[3,2-d]pyrimidin-4-one
(1)
8WK : 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
(1)
8WN : ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide
(1)
9HS : 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one
(1)
9QA : 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}quinazolin-4(3H)-one
(1)
9QD : N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide
(1)
ACT : ACETATE ION
(1)
AJJ : 4-[3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]phenol
(1)
CA : CALCIUM ION
(1)
CQ5 : 3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]-6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-one
(1)
DMS : DIMETHYL SULFOXIDE
(1)
EPE : 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
(1)
MAN : alpha-D-mannopyranose
(1)
MLA : MALONIC ACID
(1)
P6G : HEXAETHYLENE GLYCOL
(1)
ZN : ZINC ION
(1)
 
Function and Biology
EC number / name  (1)
3.4.19.12 : Ubiquitinyl hydrolase 1
(22)
 
Biological function  (1)
cysteine-type deubiquitinase activity
(22)
 
Biological process  (1)
protein deubiquitination
(22)
 
Biological cell component  (1)
extracellular region
(3)
 
Sequence and Structure classification
SCOP fold  (1)
Cysteine proteinases
(2)
 
SCOP family  (1)
Ubiquitin carboxyl-terminal hydrolase, UCH
(2)
 
CATH class  (2)
Mainly Beta
(40)
Alpha Beta
(15)
 
CATH topology  (5)
ubp-family deubiquitinating enzyme fold
(40)
Alpha-Beta Plaits
(15)
Immunoglobulin-like
(3)
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
(3)
Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
(1)
 
Pfam accession / name  (6)
PF00443 : UCH
(22)
PF09408 : bCoV_S1_RBD
(15)
PF01759 : NTR
(3)
PF07677 : A2M_recep
(3)
PF21308 : C3_CUB2
(3)
PF22486 : MATH_2
(1)
 
Experimental Information
Diffraction protocol  (1)
Single wavelength
(40)
 
Diffraction radiation source type  (2)
Synchrotron
(38)
Rotating anode
(2)
 
Diffraction source  (21)
APS BEAMLINE 22-ID
(5)
SSRF BEAMLINE BL17U
(5)
ALS BEAMLINE 5.0.2
(4)
APS BEAMLINE 24-ID-C
(4)
APS BEAMLINE 21-ID-G
(2)
APS BEAMLINE 22-BM
(2)
ESRF BEAMLINE ID23-1
(2)
ESRF BEAMLINE MASSIF-1
(2)
SSRL BEAMLINE BL12-2
(2)
APS BEAMLINE 19-ID
(1)
BRUKER AXS MICROSTAR
(1)
CHESS BEAMLINE A1
(1)
DIAMOND BEAMLINE I03
(1)
DIAMOND BEAMLINE I04
(1)
NSLS BEAMLINE X25
(1)
PHOTON FACTORY BEAMLINE BL-5A
(1)
RIGAKU RU200
(1)
SSRF BEAMLINE BL17U1
(1)
SSRF BEAMLINE BL19U1
(1)
SSRL BEAMLINE BL11-1
(1)
SSRL BEAMLINE BL7-1
(1)
 
Synchrotron site  (9)
APS
(14)
SSRF
(7)
ALS
(4)
ESRF
(4)
SSRL
(4)
Diamond
(2)
CHESS
(1)
NSLS
(1)
Photon Factory
(1)
 
Diffraction detector type  (3)
CCD
(27)
Pixel
(10)
Image plate
(3)
 
Refinement software  (4)
PHENIX
(29)
REFMAC
(8)
CNS
(3)
BUSTER
(1)
 
Representative Structures
Representative Structures
100%
95%
90%
70%
50%
40%
30%
Entries 1 to 10 of 40
Entries 1 to 10 of 40
 Select all entries on this page
Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein
Zhang S, Wang P, Zhou P, Wang X, Zhang L
Cell Rep (2018) [PMID: 29996104  ]
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Assembly name: Spike protein S2' and IG-heavy chain and IG-light lambda chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-207951 (Preferred)   search this ID
PDBe-KB: K9N5Q8   
X-ray diffraction
2.8Å resolution
Released: 1 Aug 2018
Model geometry
Fit model/data
5yy5
5yy5
5yy5
Complex structure of MERS-RBD bound with 4C2 antibody
Li Y, Wan Y, Liu P, Zhao J, Lu G, Qi J, Wang Q, Lu X, Wu Y, Liu W, Yuen KY, Perlman S, Gao GF, Yan J
Cell Res (2015) [PMID: 26391698  ]
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Assembly name: Spike glycoprotein and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-234971 (Preferred)   search this ID
PDBe-KB: K0BRG7   
X-ray diffraction
2.409Å resolution
Released: 14 Oct 2015
Model geometry
Fit model/data
5do2
5do2
5do2
Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque in complex with MERS Receptor Binding Domain
Joyce MG, Mascola JR, Graham BS, Kwong PD
J Virol (2018) [PMID: 29514901  ]
Assembly composition: protein/protein complex
Bound ligands: SO4   
Assembly name: Spike protein S2' and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-230683 (Preferred)   search this ID
PDBe-KB: K9N5Q8   
X-ray diffraction
3.32Å resolution
Released: 7 Mar 2018
Model geometry
Fit model/data
6c6y
6c6y
6c6y
Crystal structure of potent neutralizing antibody CDC2-C2 in complex with MERS-CoV S1 RBD
Wang N, McLellan JS
J Virol (2018) [PMID: 29514901  ]
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Assembly name: Spike protein S2' and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-230684 (Preferred)   search this ID
PDBe-KB: K9N5Q8   
X-ray diffraction
2.1Å resolution
Released: 31 Jan 2018
Model geometry
Fit model/data
6c6z
6c6z
6c6z
Structure of MERS-CoV RBD in complex with a fully human antibody MCA1
Chen C, Wang JM, Zou TT, Gao XP, Cui S, Jin Q
J Infect Dis (2017) [PMID: 28472421  ]
Assembly composition: protein/protein complex
Bound ligands: EDO   
Carbohydrate polymer components:
Molecule 1 - MAN(2), NAG(1)
Assembly name: Spike protein S2' and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-234973 (Preferred)   search this ID
PDBe-KB: K9N5Q8   
X-ray diffraction
2.703Å resolution
Released: 31 May 2017
Model geometry
Fit model/data
5gmq
5gmq
5gmq
Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 2)
Joyce MG, Mascola JR, Graham BS, Kwong PD
Nat Commun (2015) [PMID: 26218507  ]
Assembly composition: protein/protein complex
Bound ligands: NAG    NAG   
Assembly name: Spike protein S2' and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-207949 (Preferred)   search this ID
PDBe-KB: K9N5Q8   
X-ray diffraction
3.2Å resolution
Released: 21 Oct 2015
Model geometry
Fit model/data
4zpv
4zpv
4zpv
Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus
Chen Y, Rajashankar KR, Yang Y, Agnihothram SS, Liu C, Lin Y-L, Baric RS, Li F
J Virol (2013) [PMID: 23903833  ]
Assembly composition: protein only structure
Bound ligands: EDO   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Assembly name: Spike glycoprotein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-126025 (Preferred)   search this ID
PDBe-KB: M4SVE7   
X-ray diffraction
2.13Å resolution
Released: 31 Jul 2013
Model geometry
Fit model/data
4l3n
4l3n
4l3n
Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD
Zhou T, Dimtrov DS, Ying T
Nat Commun (2015) [PMID: 26370782  ]
Assembly composition: protein/protein complex
Bound ligands: GOL    NAG    NAG   
Assembly name: Spike protein S2' and IG-heavy chain and IG-light kappa chain (Preferred)   search this complex
PDBe complex ID: PDB-CPX-229731 (Preferred)   search this ID
PDBe-KB: K9N5Q8   
X-ray diffraction
2.45Å resolution
Released: 26 Aug 2015
Model geometry
Fit model/data
4xak
4xak
4xak
structure of the receptor binding domain (RBD) of MERS-CoV spike
Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J, Zhang B, Shi Y, Yan J, Gao GF
Nature (2013) [PMID: 23831647  ]
Assembly composition: protein only structure
Bound ligands: NAG    NAG   
Assembly name: Spike glycoprotein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-125454 (Preferred)   search this ID
PDBe-KB: K0BRG7   
X-ray diffraction
2.514Å resolution
Released: 10 Jul 2013
Model geometry
Fit model/data
4kqz
4kqz
4kqz
Crystal structure of MERS-CoV complexed with human DPP4
Wang XQ, Wang NS
Cell Res (2013) [PMID: 23835475  ]
Bound ligands: NAG    NAG   
Carbohydrate polymer components:
Molecule 1 - NAG(2)
Molecule 2 - BMA(1), NAG(2)
Assembly name: Dipeptidyl peptidase 4 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151015 (Preferred)   search this ID
PDBe-KB: R9UQ53    P27487   
X-ray diffraction
3.005Å resolution
Released: 21 Aug 2013
Model geometry
Fit model/data
4l72
4l72
4l72
Entries 1 to 10 of 40
Entries 1 to 10 of 40