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Naja kaouthia
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Human betacoronavirus 2c EMC/2012
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Deubiquitinating enzyme 7
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Herpesvirus-associated ubiquitin-specific protease
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Ubiquitin carboxyl-terminal hydrolase 7
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Ubiquitin thioesterase 7
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E2
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2
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3
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S
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Interacting ligands
(27)
NAG : 2-acetamido-2-deoxy-beta-D-glucopyranose
(15)
GOL : GLYCEROL
(8)
SO4 : SULFATE ION
(3)
BMA : beta-D-mannopyranose
(2)
BR : BROMIDE ION
(2)
EDO : 1,2-ETHANEDIOL
(2)
MG : MAGNESIUM ION
(2)
PO4 : PHOSPHATE ION
(2)
8JM : 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl]phenol
(1)
8JP : 6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl[3,3'-bipyridine]-6-carboxamide
(1)
8QQ : 3-[4-(aminomethyl)phenyl]-2-methyl-6-[[4-oxidanyl-1-[(3~{R})-4,4,4-tris(fluoranyl)-3-phenyl-butanoyl]piperidin-4-yl]methyl]pyrazolo[4,3-d]pyrimidin-7-one
(1)
8RN : 7-bromanyl-3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]thieno[3,2-d]pyrimidin-4-one
(1)
8WK : 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
(1)
8WN : ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide
(1)
9HS : 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one
(1)
9QA : 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}quinazolin-4(3H)-one
(1)
9QD : N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide
(1)
ACT : ACETATE ION
(1)
AJJ : 4-[3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]phenol
(1)
CA : CALCIUM ION
(1)
CQ5 : 3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]-6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-one
(1)
DMS : DIMETHYL SULFOXIDE
(1)
EPE : 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
(1)
MAN : alpha-D-mannopyranose
(1)
MLA : MALONIC ACID
(1)
P6G : HEXAETHYLENE GLYCOL
(1)
ZN : ZINC ION
(1)
Function and Biology
EC number / name
(1)
3.4.19.12 : Ubiquitinyl hydrolase 1
(22)
Biological function
(1)
cysteine-type deubiquitinase activity
(22)
Biological process
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protein deubiquitination
(22)
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extracellular region
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Sequence and Structure classification
SCOP fold
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Cysteine proteinases
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Ubiquitin carboxyl-terminal hydrolase, UCH
(2)
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Mainly Beta
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(5)
ubp-family deubiquitinating enzyme fold
(40)
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Immunoglobulin-like
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OB fold (Dihydrolipoamide Acetyltransferase, E2P)
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Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
(1)
Pfam accession / name
(6)
PF00443 : UCH
(22)
PF09408 : bCoV_S1_RBD
(15)
PF01759 : NTR
(3)
PF07677 : A2M_recep
(3)
PF21308 : C3_CUB2
(3)
PF22486 : MATH_2
(1)
Experimental Information
Diffraction protocol
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Single wavelength
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Diffraction radiation source type
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Synchrotron
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Rotating anode
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Diffraction source
(21)
APS BEAMLINE 22-ID
(5)
SSRF BEAMLINE BL17U
(5)
ALS BEAMLINE 5.0.2
(4)
APS BEAMLINE 24-ID-C
(4)
APS BEAMLINE 21-ID-G
(2)
APS BEAMLINE 22-BM
(2)
ESRF BEAMLINE ID23-1
(2)
ESRF BEAMLINE MASSIF-1
(2)
SSRL BEAMLINE BL12-2
(2)
APS BEAMLINE 19-ID
(1)
BRUKER AXS MICROSTAR
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CHESS BEAMLINE A1
(1)
DIAMOND BEAMLINE I03
(1)
DIAMOND BEAMLINE I04
(1)
NSLS BEAMLINE X25
(1)
PHOTON FACTORY BEAMLINE BL-5A
(1)
RIGAKU RU200
(1)
SSRF BEAMLINE BL17U1
(1)
SSRF BEAMLINE BL19U1
(1)
SSRL BEAMLINE BL11-1
(1)
SSRL BEAMLINE BL7-1
(1)
Synchrotron site
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APS
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SSRF
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ALS
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ESRF
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SSRL
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Diamond
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CHESS
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NSLS
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Photon Factory
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Diffraction detector type
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CCD
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Pixel
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Image plate
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Refinement software
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PHENIX
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REFMAC
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CNS
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BUSTER
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Representative Structures
Representative Structures
Entries
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Entries 1 to 10 of 40
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Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein
Zhang S, Wang P, Zhou P, Wang X, Zhang L
Cell Rep
(2018)
[PMID: 29996104 ]
Source organisms: Middle East respiratory syndrome-related coronavirus , Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Spike protein S2' and IG-heavy chain and IG-light lambda chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-207951 (Preferred)
search this ID

Complex structure of MERS-RBD bound with 4C2 antibody
Li Y, Wan Y, Liu P, Zhao J, Lu G, Qi J, Wang Q, Lu X, Wu Y, Liu W, Yuen KY, Perlman S, Gao GF, Yan J
Cell Res
(2015)
[PMID: 26391698 ]
Source organisms: Middle East respiratory syndrome-related coronavirus , Mus musculus
Assembly composition: protein/protein complex
Assembly name:
Spike glycoprotein and IG-heavy chain and IG-light kappa chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-234971 (Preferred)
search this ID

Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque in complex with MERS Receptor Binding Domain
Joyce MG, Mascola JR, Graham BS, Kwong PD
J Virol
(2018)
[PMID: 29514901 ]
Source organisms: Betacoronavirus England 1 , Macaca mulatta
Assembly composition: protein/protein complex
Bound ligands:
SO4
Assembly name:
Spike protein S2' and IG-heavy chain and IG-light kappa chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-230683 (Preferred)
search this ID

Crystal structure of potent neutralizing antibody CDC2-C2 in complex with MERS-CoV S1 RBD
Wang N, McLellan JS
J Virol
(2018)
[PMID: 29514901 ]
Source organisms: Middle East respiratory syndrome-related coronavirus , Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Spike protein S2' and IG-heavy chain and IG-light kappa chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-230684 (Preferred)
search this ID

Structure of MERS-CoV RBD in complex with a fully human antibody MCA1
Chen C, Wang JM, Zou TT, Gao XP, Cui S, Jin Q
J Infect Dis
(2017)
[PMID: 28472421 ]
Source organisms: Middle East respiratory syndrome-related coronavirus , Homo sapiens
Assembly composition: protein/protein complex
Bound ligands:
EDO
Carbohydrate polymer components:
Molecule 1 -
MAN(2), NAG(1)
Assembly name:
Spike protein S2' and IG-heavy chain and IG-light kappa chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-234973 (Preferred)
search this ID

Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 2)
Joyce MG, Mascola JR, Graham BS, Kwong PD
Nat Commun
(2015)
[PMID: 26218507 ]
Source organisms: Betacoronavirus England 1 , Mus musculus
Assembly composition: protein/protein complex
Assembly name:
Spike protein S2' and IG-heavy chain and IG-light kappa chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-207949 (Preferred)
search this ID

Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus
Chen Y, Rajashankar KR, Yang Y, Agnihothram SS, Liu C, Lin Y-L, Baric RS, Li F
J Virol
(2013)
[PMID: 23903833 ]
Source organism: Human betacoronavirus 2c Jordan-N3/2012
Assembly composition: protein only structure
Bound ligands:
EDO
Carbohydrate polymer components:
Molecule 1 -
NAG(2)
Assembly name:
Spike glycoprotein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-126025 (Preferred)
search this ID

Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD
Zhou T, Dimtrov DS, Ying T
Nat Commun
(2015)
[PMID: 26370782 ]
Source organisms: Betacoronavirus England 1 , Homo sapiens
Assembly composition: protein/protein complex
Assembly name:
Spike protein S2' and IG-heavy chain and IG-light kappa chain
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-229731 (Preferred)
search this ID

structure of the receptor binding domain (RBD) of MERS-CoV spike
Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J, Zhang B, Shi Y, Yan J, Gao GF
Nature
(2013)
[PMID: 23831647 ]
Source organism: Human betacoronavirus 2c EMC/2012
Assembly composition: protein only structure
Assembly name:
Spike glycoprotein
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-125454 (Preferred)
search this ID

Crystal structure of MERS-CoV complexed with human DPP4
Wang XQ, Wang NS
Cell Res
(2013)
[PMID: 23835475 ]
Source organisms: Middle East respiratory syndrome-related coronavirus , Homo sapiens
Carbohydrate polymer components:
Molecule 1 -
NAG(2)
Molecule 2 -
BMA(1), NAG(2)
Assembly name:
Dipeptidyl peptidase 4
(Preferred)
search this complex
PDBe complex ID:
PDB-CPX-151015 (Preferred)
search this ID
Entries 1 to 10 of 40