Profilin-1

Gene:

PFN1 Disease Amyotrophic lateral sclerosis 18: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent... [click for more]

Organism:

Homo sapiens (Human)

Uniprot:

P07737go to UniProt

Biological function:

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of ARgo to UniProt

Representative structure for UniProt P07737

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PDB 4x25 chain B (observed residues)
PDB 4x25 chain B (observed residues)
PDB 4x25 chain B (observed residues)
PDB 4x25 chain B (observed residues)
PDB 4x25 chain B (observed residues)
PDB 4x25 chain B (observed residues)

PDB chain shown: 4x25 B go to PDBe

UniProt residues 1 - 140

Coverage: 94%

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22
Structures

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19
Ligands

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12
Interactions

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21
Similarity

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115
Publications

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