Cathepsin S

Gene:

CTSS Enzyme: EC 3.4.22.27 This enzyme has known catalytic activity involved in reaction: Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.

Organism:

Homo sapiens (Human)

Uniprot:

P25774go to UniProt

Biological function:

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin Lgo to UniProt

Representative structure for UniProt P25774

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PDB 2c0y chain A (observed residues)
PDB 2c0y chain A (observed residues)
PDB 2c0y chain A (observed residues)
PDB 2c0y chain A (observed residues)

PDB chain shown: 2c0y A go to PDBe

UniProt residues 17 - 331

Coverage: 93%

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62
Structures

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74
Ligands

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22
Similarity

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73
Publications

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