- Display observed secondary structure variance per amino acid residue
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
DYRK1A Enzyme: EC 2.7.11.23 This enzyme has known catalytic activity involved in reaction: [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+) Disease Intellectual developmental disorder, autosomal dominant 7: A disease characterized by primary microcephaly, severe intellectual disability without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Intellectual disability is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period... [click for more]
Homo sapiens (Human)
DYRK, MNB, MNBH
Q13627go to UniProt
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage ... [show more]go to UniProt
Representative structure for UniProt Q13627
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