E3 ubiquitin-protein ligase pellino homolog 2

Organism:

Homo sapiens (Human)

Uniprot:
Biological function:

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) ... [show more]go to UniProt


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PDB 3egb chain A (observed residues)
PDB 3egb chain A (observed residues)
PDB 3egb chain A (observed residues)
PDB 3egb chain A (observed residues)
PDB 3egb chain A (observed residues)
PDB 3egb chain A (observed residues)
PDB 3egb chain A (observed residues)
PDB 3egb chain A (observed residues)
PDB 3egb chain A (observed residues)
PDB 3egb chain A (observed residues)

PDB chain shown: 3egb A go to PDBe

UniProt residues 7 - 289

Coverage: 57%

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2
Structures

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1
Ligands

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0
Interactions



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0
Similarity


19
Publications

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