- Display observed secondary structure variance per amino acid residue
E3 ubiquitin-protein ligase pellino homolog 2
Homo sapiens (Human)
Q9HAT8go to UniProt
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) ... [show more]go to UniProt
Representative structure for UniProt Q9HAT8
Use the arrows or click on the blue segments at the bottom to navigate between representative chains from different PDB entries for different regions of the sequence.
Observed regions are darker shades, while unobserved regions are slightly transparent.
Note: There is a reported problem with Safari 15.1 that breaks the 3D viewer, Mol*. If Mol* is not displayed for you, please try a different browser, or update your Safari browser.