- Display observed secondary structure variance per amino acid residue
Tyrosine-protein kinase BTK
BTK Enzyme: EC 2.7.10.2 This enzyme has known catalytic activity involved in reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) Disease X-linked agammaglobulinemia: Humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes... [click for more]
Homo sapiens (Human)
AGMX1, ATK, BPK
Q06187go to UniProt
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by ... [show more]go to UniProt
Representative structures for UniProt Q06187
Use the arrows or click on the blue segments at the bottom to navigate between representative chains from different PDB entries for different regions of the sequence.
Observed regions are darker shades, while unobserved regions are slightly transparent.
Note: There is a reported problem with Safari 15.1 that breaks the 3D viewer, Mol*. If Mol* is not displayed for you, please try a different browser, or update your Safari browser.