- Display observed secondary structure variance per amino acid residue
Beta-secretase 1
Homo sapiens (Human)
BACE, KIAA1149
P56817go to UniProt
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, [show more]go to UniProt
Representative structure for UniProt P56817
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Observed regions are darker shades, while unobserved regions are slightly transparent.
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