- Display observed secondary structure variance per amino acid residue
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
PDE10A Enzyme: EC 3.1.4.17 This enzyme has known catalytic activity involved in reaction: 3',5'-cyclic GMP + H2O = GMP + H(+) Disease Dyskinesia, limb and orofacial, infantile-onset: An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable... [click for more]
Homo sapiens (Human)
Q9Y233go to UniProt
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:17389385, PubMed:27058447). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, [show more]go to UniProt
Representative structures for UniProt Q9Y233
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