Poly(ADP-ribose) glycohydrolase

Gene:

Parg Enzyme: EC 3.2.1.143 This enzyme has known catalytic activity involved in reaction: [(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose

Organism:

Mus musculus (Mouse)

Uniprot:

O88622go to UniProt

Biological function:

Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only ... [show more]go to UniProt

Representative structure for UniProt O88622

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PDB 4na5 chain A (observed residues)
PDB 4na5 chain A (observed residues)
PDB 4na5 chain A (observed residues)
PDB 4na5 chain A (observed residues)
PDB 4na5 chain A (observed residues)
PDB 4na5 chain A (observed residues)

PDB chain shown: 4na5 A go to PDBe

UniProt residues 439 - 959

Coverage: 52%

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7
Structures

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5
Ligands

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0
Interactions



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2
Similarity

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14
Publications

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