Mitogen-activated protein kinase kinase kinase 5

Gene:

MAP3K5 Enzyme: EC 2.7.11.25 This enzyme has known catalytic activity involved in reaction: L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)

Organism:

Homo sapiens (Human)

Synonyms:

ASK1, MAPKKK5, MEKK5

Uniprot:

Q99683go to UniProt

Biological function:

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required ... [show more]go to UniProt

Representative structure for UniProt Q99683

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PDB 8qgy chain B (observed residues)
PDB 8qgy chain B (observed residues)
PDB 8qgy chain B (observed residues)
PDB 8qgy chain B (observed residues)
PDB 8qgy chain B (observed residues)
PDB 8qgy chain B (observed residues)

PDB chain shown: 8qgy B go to PDBe

UniProt residues 88 - 976

Coverage: 59%

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27
Structures

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28
Ligands

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0
Similarity


125
Publications

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