- Display observed secondary structure variance per amino acid residue
DNA repair nuclease/redox regulator APEX1
Homo sapiens (Human)
APE, APE1, APEX, APX, HAP1, REF1
P27695go to UniProt
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by ... [show more]go to UniProt
Representative structure for UniProt P27695
Use the arrows or click on the blue segments at the bottom to navigate between representative chains from different PDB entries for different regions of the sequence.
Observed regions are darker shades, while unobserved regions are slightly transparent.
Note: There is a reported problem with Safari 15.1 that breaks the 3D viewer, Mol*. If Mol* is not displayed for you, please try a different browser, or update your Safari browser.