- Display observed secondary structure variance per amino acid residue
Tyrosine-protein phosphatase non-receptor type 1
Homo sapiens (Human)
PTP1B
P18031go to UniProt
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through ... [show more]go to UniProt
Representative structure for UniProt P18031
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