NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Gene:

SIRT3 Enzyme: EC 2.3.1.286 This enzyme has known catalytic activity involved in reaction: N(6)-[(S)-lactoyl]-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-(S)-lactoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]

Organism:

Homo sapiens (Human)

Synonyms:

SIR2L3

Uniprot:

Q9NTG7go to UniProt

Biological function:

NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:19535340, PubMed:23283301, PubMed:24121500, PubMed:24252090). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, [show more]go to UniProt

Representative structure for UniProt Q9NTG7

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PDB 8bbk chain C (observed residues)
PDB 8bbk chain C (observed residues)

PDB chain shown: 8bbk C go to PDBe

UniProt residues 1 - 399

Coverage: 69%

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42
Structures

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43
Ligands

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Interactions

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22
Similarity

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Publications