Protein argonaute-3

Gene:

AGO3 Enzyme: EC 3.1.26.n2 This enzyme has known catalytic activity involved in reaction: Endonucleolytic cleavage to 5'-phosphomonoester.

Organism:

Homo sapiens (Human)

Synonyms:

EIF2C3

Uniprot:

Q9H9G7go to UniProt

Biological function:

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent ... [show more]go to UniProt

Representative structure for UniProt Q9H9G7

PDB chain with highest data quality, coverage and best resolution This viewer shows non-overlapping chains from PDB entries with the highest number of observed residues for various regions of the UniProt protein sequence.

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PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)
PDB 8vaj chain A (observed residues)

PDB chain shown: 8vaj A go to PDBe

UniProt residues 1 - 860

Coverage: 96%

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2
Structures

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0
Ligands


1
Interactions

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Annotations

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25
Similarity

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33
Publications

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