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E3 ubiquitin-protein ligase ipaH9.8
Shigella flexneri serotype X (strain 2002017)
D2AJU0go to UniProt
Effector E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. Interacts with IKBKG (NEMO) and TNIP1 (ABIN-1), a ubiquitin-binding adapter protein, which results in TNIP1-dependent 'Lys-27'-linked polyubiquitination of IKBKG. Consequently, polyubiquitinated IKBKG undergoes proteasome-dependent degradation, which perturbs NF-kappa-B activation during bacterial infection. Mediates polyubiquitination of host ... [show more]go to UniProt
Representative structure for UniProt D2AJU0
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PDB chain shown: 6loj A go to PDBe
UniProt residues 22 - 244
Coverage: 40%