E3 ubiquitin-protein ligase ipaH9.8

Organism:

Shigella flexneri serotype X (strain 2002017)

Uniprot:
Biological function:

Effector E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. Interacts with IKBKG (NEMO) and TNIP1 (ABIN-1), a ubiquitin-binding adapter protein, which results in TNIP1-dependent 'Lys-27'-linked polyubiquitination of IKBKG. Consequently, polyubiquitinated IKBKG undergoes proteasome-dependent degradation, which perturbs NF-kappa-B activation during bacterial infection. Mediates polyubiquitination of host ... [show more]go to UniProt


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PDB 6loj chain A (observed residues)
PDB 6loj chain A (observed residues)

PDB chain shown: 6loj A go to PDBe

UniProt residues 22 - 244

Coverage: 40%

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21
Similarity

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5
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