Dihydrofolate reductase

Gene:

DHFR Enzyme: EC 1.5.1.3 This enzyme has known catalytic activity involved in reaction: (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)

Organism:

Schistosoma mansoni (Blood fluke)

Uniprot:

G4VJD6go to UniProt

Biological function:

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesisgo to UniProt

Representative structure for UniProt G4VJD6

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PDB 3vco chain A (observed residues)
PDB 3vco chain A (observed residues)

PDB chain shown: 3vco A go to PDBe

UniProt residues 1 - 181

Coverage: 97%

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