DNA-directed RNA polymerase III subunit RPC1 (O14802)

Publications
Primary PDB publications, reviews associated with PDB entries and UniProt publications are listed below. Click on the plus/minus signs to expand/collapse the publication lists.
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PDB publications (6)
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Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters.
Shah SZ, Perry TN, Graziadei A, Cecatiello V, Kaliyappan T et al.
Nat Commun 1 141 (2025)
Related PDB entries: 9fso go to PDBe,  9fsp go to PDBe,  9fsq go to PDBe,  9fsr go to PDBe,  9fss go to PDBe 
Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Hou H, Jin Q, Ren Y, Chen Z, Wang Q et al.
Cell Res (2023)
Related PDB entries: 8ity go to PDBe,  8iue go to PDBe,  8iuh go to PDBe 
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Girbig M, Misiaszek AD, Vorländer MK, Lafita A, Grötsch H et al.
Nat Struct Mol Biol 2 210-219 (2021)
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe 
Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.
Hou H, Li Y, Wang M, Liu A, Yu Z et al.
Nat Commun 1 6135 (2021)
Related PDB entries: 7fji go to PDBe,  7fjj go to PDBe 
Structural insights into transcriptional regulation of human RNA polymerase III.
Wang Q, Li S, Wan F, Xu Y, Wu Z et al.
Nat Struct Mol Biol 2 220-227 (2021)
Related PDB entries: 7d58 go to PDBe,  7d59 go to PDBe 
Structure of human RNA polymerase III elongation complex.
Li L, Yu Z, Zhao D, Ren Y, Hou H et al.
Cell Res 7 791-800 (2021)
Related PDB entries: 7dn3 go to PDBe,  7du2 go to PDBe 
PDB-related reviews (13)
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RNA Polymerases I and III in development and disease.
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe,  7dn3 go to PDBe,  7du2 go to PDBe 
Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes.
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe,  7d58 go to PDBe,  7d59 go to PDBe 
Embracing Heterogeneity: Challenging the Paradigm of Replisomes as Deterministic Machines.
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe 
Iron-sulfur clusters as inhibitors and catalysts of viral replication.
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe,  7d58 go to PDBe,  7d59 go to PDBe 
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases.
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe,  7d58 go to PDBe,  7d59 go to PDBe,  7dn3 go to PDBe,  7du2 go to PDBe,  7fji go to PDBe,  7fjj go to PDBe 
How to Shut Down Transcription in Archaea during Virus Infection.
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe 
RNA polymerase III transcription and cancer: A tale of two RPC7 subunits.
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe,  7d58 go to PDBe,  7dn3 go to PDBe,  7du2 go to PDBe 
Specific Features of RNA Polymerases I and III: Structure and Assembly.
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe,  7d58 go to PDBe,  7d59 go to PDBe,  7dn3 go to PDBe,  7du2 go to PDBe 
RNA Polymerase III, Ageing and Longevity.
Related PDB entries: 7a6h go to PDBe,  7ae1 go to PDBe,  7ae3 go to PDBe,  7aea go to PDBe 
RNA Polymerase III Subunit Mutations in Genetic Diseases.
Related PDB entries: 7a6h go to PDBe,  7aea go to PDBe,  7d58 go to PDBe,  7d59 go to PDBe,  7dn3 go to PDBe,  7du2 go to PDBe 
UniProt publications (25)
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A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A non-coding RNA.
Van Bortle K., Marciano D.P., Liu Q., Chou T., Lipchik A.M. et al.
Nat. Commun. 3007-3007 (2022)
Structure of human RNA polymerase III elongation complex.
Li L., Yu Z., Zhao D., Ren Y., Hou H. et al.
Cell Res. 791-800 (2021)
Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.
Hou H., Li Y., Wang M., Liu A., Yu Z. et al.
Nat. Commun. 6135-6146 (2021)
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Girbig M., Misiaszek A.D., Vorlander M.K., Lafita A., Grotsch H. et al.
Nat. Struct. Mol. Biol. 210-219 (2021)
Structural insights into transcriptional regulation of human RNA polymerase III.
Wang Q., Li S., Wan F., Xu Y., Wu Z. et al.
Nat. Struct. Mol. Biol. 220-227 (2021)
Structure of human RNA polymerase III.
Ramsay E.P., Abascal-Palacios G., Daiss J.L., King H., Gouge J. et al.
Nat. Commun. 6409-6421 (2020)
Bi-allelic POLR3A loss-of-function variants cause autosomal-recessive Wiedemann-Rautenstrauch syndrome.
Wambach J.A., Wegner D.J., Patni N., Kircher M., Willing M.C. et al.
Am. J. Hum. Genet. 968-975 (2018)
Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann-Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations.
Lessel D., Ozel A.B., Campbell S.E., Saadi A., Arlt M.F. et al.
Hum. Genet. 921-939 (2018)
Specific combinations of biallelic POLR3A variants cause Wiedemann-Rautenstrauch syndrome.
Paolacci S., Li Y., Agolini E., Bellacchio E., Arboleda-Bustos C.E. et al.
J. Med. Genet. 837-846 (2018)
Neonatal progeriod syndrome associated with biallelic truncating variants in POLR3A.
Jay A.M., Conway R.L., Thiffault I., Saunders C., Farrow E. et al.
Am. J. Med. Genet. A 3343-3346 (2016)