Bifunctional polymyxin resistance protein ArnA

Gene:

arnA Enzyme: EC 1.1.1.305 This enzyme has known catalytic activity involved in reaction: UDP-4-amino-4-deoxy-beta-L-arabinose + (6R)-10-formyltetrahydrofolate = UDP-4-deoxy-4-formamido-beta-L-arabinose + (6S)-5,6,7,8-tetrahydrofolate + H(+)

Organism:

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Synonyms:

pbgP3, pmrI

Uniprot:

O52325go to UniProt

Biological function:

Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)go to UniProt

Representative structure for UniProt O52325

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PDB 8gjh chain B (observed residues)
PDB 8gjh chain B (observed residues)
PDB 8gjh chain B (observed residues)
PDB 8gjh chain B (observed residues)
PDB 8gjh chain B (observed residues)
PDB 8gjh chain B (observed residues)

PDB chain shown: 8gjh B go to PDBe

UniProt residues 1 - 660

Coverage: 97%

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