Serine/threonine-protein kinase Chk2

Gene:

CHEK2 Enzyme: EC 2.7.11.1 This enzyme has known catalytic activity involved in reaction: L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) Disease Tumor predisposition syndrome 4: A disorder characterized by an increased risk for developing various types of benign and/or malignant neoplasms that arise at an accelerated rate and in different organs.Prostate cancer: A malignancy originating in tissues of the prostate... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

CDS1, CHK2, RAD53

Uniprot:

O96017go to UniProt

Biological function:

(Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activitygo to UniProt

Representative structures for UniProt O96017

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PDB 3va4 chain B (observed residues)
PDB 3va4 chain B (observed residues)
PDB 3i6u chain B (observed residues)
PDB 3i6u chain B (observed residues)
PDB 3i6u chain B (observed residues)
PDB 3i6u chain B (observed residues)
PDB 3i6u chain B (observed residues)
PDB 3i6u chain B (observed residues)
PDB 3i6u chain B (observed residues)
PDB 3i6u chain B (observed residues)
PDB 3i6u chain B (observed residues)
PDB 3i6u chain B (observed residues)

PDB chain shown: 3va4 B go to PDBe

UniProt residues 63 - 73

Coverage: 1%

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38
Structures

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54
Similarity

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155
Publications

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