Aggregated Views of Proteins
Serine/threonine-protein kinase Chk2 (O96017)
Annotations
This section shows residue-level functional annotations available for the PDB entries related to this protein. These annotations are contributed by members of the PDBe-KB consortium or generated by weekly data pipelines. For more information see the PDBe-KB Wiki pages.
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Annotated Residues
The visualisation is using UniProt numbering for residues, not PDB numbering.
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| Curated regularity motifs | |
| Curated interface annotations | |
| Predicted functional sites | |
| Predicted PTM sites | |
| Predicted ligand binding sites | |
| Molecular channels | |
| Biophysical parameters | |
| Domains | |
| Ligand binding sites | |
| Interaction interfaces | |
Curated regularity motifs
The Protein Kinase Ontology (ProKinO) is a protein kinase-specific ontology
Curated interface annotations
3D Complex is a hierarchical classification of protein complexes that describes similarities in structure, sequence, as well as topology of contacts of the constituent proteins
Predicted functional sites
CATH-FunSites are groups of amino acid residues that are evolutionarily conserved within a CATH FunFam
Predicted PTM sites
Predictions of phosphorylation sites for kinases in target proteins
A Comprehensive Resource of Human Phosphosites within Their Full Context
Predicted ligand binding sites
P2Rank is a new open source software package for ligand binding site prediction from protein structure
Molecular channels
ChannelsDB is a database providing information about the positions, geometry and physicochemical properties of channels (pores and tunnels) found within biomacromolecular structures deposited in the Protein Data Bank
Biophysical parameters
POPSCOMP is a method to analyse interactions between individual complex components of proteins and/or nucleic acids by calculating the solvent accessible surface area (SASA) buried upon complex formation.
POPSCOMP is a method to analyse interactions between individual complex components of proteins and/or nucleic acids by calculating the solvent accessible surface area (SASA) buried upon complex formation.
POPSCOMP is a method to analyse interactions between individual complex components of proteins and/or nucleic acids by calculating the solvent accessible surface area (SASA) buried upon complex formation.
3D Complex is a hierarchical classification of protein complexes that describes similarities in structure, sequence, as well as topology of contacts of the constituent proteins
3D Complex is a hierarchical classification of protein complexes that describes similarities in structure, sequence, as well as topology of contacts of the constituent proteins
Cospi-Depth is a server for computing/predicting depth, cavity sizes, ligand binding sites and pKa
Cospi-Depth is a server for computing/predicting depth, cavity sizes, ligand binding sites and pKa
Domains
Residues mapped to CATH domains
Residues mapped to InterPro domains
Ligand binding sites
Residues binding ADENOSINE-5'-DIPHOSPHATE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/ADP_200.svg" /><span>
Residues binding 3-METHYL-4-(THIOPHEN-2-YL)-1H-PYRAZOL-5-AMINE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/WVI_200.svg" /><span>
Residues binding 3-cyclopropyl-4-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridine<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/Z2M_200.svg" /><span>
Residues binding 2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)-N-[2-(DIMETHYLAMINO)ETHYL]PYRIDINE-3-CARBOXAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/WTJ_200.svg" /><span>
Residues binding 3-(PYRIDIN-3-YL)-1H-PYRAZOL-5-AMINE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/P3J_200.svg" /><span>
Residues binding 4-[(E)-C-methyl-N-oxidanyl-carbonimidoyl]benzene-1,3-diol<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/ODO_200.svg" /><span>
Residues binding 6-METHYLQUINAZOLIN-4-AMINE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/CWS_200.svg" /><span>
Residues binding 1-(TERT-BUTYL)-3-(QUINOXALIN-6-YL)UREA<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/Z0O_200.svg" /><span>
Residues binding 3,4-dihydro[1,2,4]triazolo[1,5-a][3,1]benzimidazol-9-ium<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/VFB_200.svg" /><span>
Residues binding 2-[4-(4-CHLOROPHENOXY)PHENYL]-1H-BENZIMIDAZOLE-6-CARBOXAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/RU5_200.svg" /><span>
Residues binding 2-(4-(3-HYDROXYPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/RU9_200.svg" /><span>
Residues binding 2-{4-[(1-BENZYLPIPERIDIN-4-YL)METHOXY]PHENYL}-1H-BENZIMIDAZOLE-6-CARBOXAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/A9U_200.svg" /><span>
Residues binding 2-(4-{[1-(4-CHLOROBENZYL)PIPERIDIN-4-YL]METHOXY}PHENYL)-1H-BENZIMIDAZOLE-5-CARBOXAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/A9T_200.svg" /><span>
Residues binding 2-{4-[(3S)-PYRROLIDIN-3-YLAMINO]QUINAZOLIN-2-YL}PHENOL<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/B4W_200.svg" /><span>
Residues binding 4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL)PYRROLIDIN-3-YL]AMINO}-6,7-DIMETHOXYQUINAZOLIN-2-YL)PHENOL<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/XBJ_200.svg" /><span>
Residues binding 4-[2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)PYRIDIN-3-YL]BENZAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/WTI_200.svg" /><span>
Residues binding 4-[2-AMINO-5-(4-HYDROXY-3-METHOXYPHENYL)PYRIDIN-3-YL]BENZAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/VGM_200.svg" /><span>
Residues binding 4-[2-AMINO-5-(1,3-BENZODIOXOL-4-YL)PYRIDIN-3-YL]BENZAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/ZZK_200.svg" /><span>
Residues binding 5-METHYL-3-PHENYL-1H-PYRAZOLE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/H3R_200.svg" /><span>
Residues binding 4-(1H-pyrazol-5-yl)-2-{4-[(3S)-pyrrolidin-3-ylamino]quinazolin-2-yl}phenol<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/LWH_200.svg" /><span>
Residues binding DEBROMOHYMENIALDISINE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/DBQ_200.svg" /><span>
Residues binding 1-acetyl-N-(5-methylpyridin-2-yl)piperidine-4-carboxamide<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/HAU_200.svg" /><span>
Residues binding N-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamide<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/D1A_200.svg" /><span>
Residues binding N-{4-[(1E)-N-(N-hydroxycarbamimidoyl)ethanehydrazonoyl]phenyl}-7-nitro-1H-indole-2-carboxamide<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/XK9_200.svg" /><span>
Residues binding N-{4-[(1E)-N-carbamimidoylbutanehydrazonoyl]phenyl}-5-methoxy-1H-indole-2-carboxamide<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/YIT_200.svg" /><span>
Residues binding N-{4-[(1E)-N-CARBAMIMIDOYLETHANEHYDRAZONOYL]PHENYL}-1H-INDOLE-3-CARBOXAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/NXP_200.svg" /><span>
Residues binding 4,4'-DIACETYLDIPHENYLUREA-BIS(GUANYLHYDRAZONE)<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/ZAT_200.svg" /><span>
Residues binding (2E)-N-hydroxy-2-[1-(4-{[(4-{(1E)-1-[2-(N'-hydroxycarbamimidoyl)hydrazinylidene]ethyl}phenyl)carbamoyl]amino}phenyl)ethylidene]hydrazinecarboximidamide<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/YCF_200.svg" /><span>
Residues binding (E)-5-(1-(2-CARBAMIMIDOYLHYDRAZONO)ETHYL)-N-(1H-INDOL-6-YL)-1H-INDOLE-2-CARBOXAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/YIQ_200.svg" /><span>
Residues binding N-{4-[(1E)-N-1H-IMIDAZOL-2-YLETHANEHYDRAZONOYL]PHENYL}-7-NITRO-1H-INDOLE-2-CARBOXAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/UPX_200.svg" /><span>
Residues binding 1,3-BIS{4-[(1E)-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)ETHANEHYDRAZONOYL]PHENYL}UREA<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/HCW_200.svg" /><span>
Residues binding N-(furan-2-ylmethyl)quinoxaline-6-carboxamide<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/ODH_200.svg" /><span>
Residues binding N-[(4-methoxyphenyl)methyl]quinoxaline-6-carboxamide<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/RQQ_200.svg" /><span>
Residues binding (E)-N-(5-(2-CARBAMIMIDOYLHYDRAZONO)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)-7-NITRO-1H-INDOLE-2-CARBOXAMIDE<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/YIR_200.svg" /><span>
Residues binding CHLORIDE ION<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/CL_200.svg" /><span>
Residues binding NITRATE ION<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/NO3_200.svg" /><span>
Residues binding MAGNESIUM ION<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/MG_200.svg" /><span>
Residues binding 1,2-ETHANEDIOL<br><span style="display:inline-block;width:100%;text-align:center;margin-top:5px;"><img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/EDO_200.svg" /><span>
Interaction interfaces
Residues interacting with Serine/threonine-protein kinase Chk2 (self) (O96017)
Residues interacting with Other
Residues interacting with Mediator of DNA damage checkpoint protein 1 (Q5PSV9)
Sequence conservation
Amino acid probabilities
The amino acid probabilities are calculated using HMM profiles based on multiple sequence alignments. Click to see more details...
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Amino acid properties
Aromatic
Polar
Hydrophobic
Negative charge
Proline
Positive charge
Cysteine
Glycine
Variants
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Annotations :
Predicted annotations
Curated annotations
Domains :
CATH domains
InterPro annotations