Tissue-type plasminogen activator

Organism:

Homo sapiens (Human)

Uniprot:
Biological function:

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy ... [show more]go to UniProt


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PDB 1tpm chain A (observed residues)
PDB 1tpm chain A (observed residues)
PDB 1pk2 chain A (observed residues)
PDB 1pk2 chain A (observed residues)
PDB 1bda chain B (observed residues)
PDB 1bda chain B (observed residues)

PDB chain shown: 1tpm A go to PDBe

UniProt residues 36 - 85

Coverage: 9%

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11
Structures

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8
Ligands

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2
Interactions

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0
Similarity


107
Publications

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Processed Proteins (2):

Protein Name
Representative Structures
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Available Structural Data
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Tissue-type plasminogen activator chain A
UniProt range of the processed protein: 36 - 310
UniProt range of representative PDB 1tpm chain A: 36 - 85
 7 Number of PDB structures
 4 Number of ligands
 1 Number of interaction partners
Tissue-type plasminogen activator chain B
UniProt range of the processed protein: 311 - 562
UniProt range of representative PDB 1rtf chain B: 311 - 562
 4 Number of PDB structures
 5 Number of ligands
 2 Number of interaction partners