RAF proto-oncogene serine/threonine-protein kinase

Gene:

RAF1 Enzyme: EC 2.7.11.1 This enzyme has known catalytic activity involved in reaction: L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) Disease Noonan syndrome 5: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

RAF

Uniprot:

P04049go to UniProt

Biological function:

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) ... [show more]go to UniProt

Representative structure for UniProt P04049

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PDB 8cpd chain A (observed residues)
PDB 8cpd chain A (observed residues)
PDB 8cpd chain A (observed residues)
PDB 8cpd chain A (observed residues)
PDB 8cpd chain A (observed residues)
PDB 8cpd chain A (observed residues)

PDB chain shown: 8cpd A go to PDBe

UniProt residues 1 - 648

Coverage: 42%

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55
Structures

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37
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6
Similarity

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624
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