Complement component C8 alpha chain

Gene:

C8A Disease Complement component 8 deficiency, 1: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

Organism:

Homo sapiens (Human)

Uniprot:

P07357go to UniProt

Biological function:

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itselfgo to UniProt

Representative structure for UniProt P07357

PDB chain with highest data quality, coverage and best resolution This viewer shows non-overlapping chains from PDB entries with the highest number of observed residues for various regions of the UniProt protein sequence.

Use the arrows or click on the blue segments at the bottom to navigate between representative chains from different PDB entries for different regions of the sequence.

Observed regions are darker shades, while unobserved regions are slightly transparent.

Note: There is a reported problem with Safari 15.1 that breaks the 3D viewer, Mol*. If Mol* is not displayed for you, please try a different browser, or update your Safari browser.

 

WebGL does not seem to be available.

This can be caused by an outdated browser, graphics card driver issue, or bad weather. Sometimes, just restarting the browser helps. Also, make sure hardware acceleration is enabled in your browser.

For a list of supported browsers, refer to http://caniuse.com/#feat=webgl.

 
PDB 8b0g chain D (observed residues)
PDB 8b0g chain D (observed residues)
PDB 8b0g chain D (observed residues)
PDB 8b0g chain D (observed residues)
PDB 8b0g chain D (observed residues)
PDB 8b0g chain D (observed residues)

PDB chain shown: 8b0g D go to PDBe

UniProt residues 1 - 584

Coverage: 88%

View all the superposed structural clusters of this protein region
Click on the icons below to view the relevant page:


11
Structures

Click on this icon to see all the PDB entries available for this protein
Click to download files
View all the structural clusters of this protein


8
Ligands

Click on this icon to see all the ligands observed in the same PDB entries as this protein. These can be further filtered to only show ligands that directly interact with the protein of interest with a distance cutoff of 5 Angstrom according to the Arpeggio tool
Click to download files
View all the ligands superposed on this protein


4
Interactions

Click on this icon to see all the macromolecular interaction partners observed in the same PDB entries as this protein
Click to download files



Annotations

Click on this icon to see all the additional annotations derived from PDB structures for this protein


10
Similarity

Click on this icon to see all the proteins that either have associated PDBs with sequence identities of 90%+ to the protein of interest, or belong to the same UniRef90 cluster


108
Publications

Click on this icon to see all the primary PDB publications, publications from UniProt and other reviews