Zinc finger protein GLI1

Gene:

GLI1 Disease Polydactyly, postaxial, A8: A form of postaxial polydactyly, a condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal... [click for more]

Organism:

Homo sapiens (Human)

Synonyms:

GLI

Uniprot:

P08151go to UniProt

Biological function:

Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migrationgo to UniProt

Representative structures for UniProt P08151

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PDB 4kmd chain B (observed residues)
PDB 4kmd chain B (observed residues)
PDB 7t91 chain B (observed residues)
PDB 7t91 chain B (observed residues)
PDB 5om0 chain B (observed residues)
PDB 5om0 chain B (observed residues)

PDB chain shown: 4kmd B go to PDBe

UniProt residues 112 - 128

Coverage: 1%

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5
Structures

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7
Ligands

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7
Similarity

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114
Publications

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