Poly [ADP-ribose] polymerase 1

Gene:

PARP1 Enzyme: EC 2.4.2.30 This enzyme has known catalytic activity involved in reaction: L-histidyl-[protein] + NAD(+) = N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide + H(+)

Organism:

Homo sapiens (Human)

Synonyms:

ADPRT, PPOL

Uniprot:

P09874go to UniProt

Biological function:

This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosisgo to UniProt

Representative structures for UniProt P09874

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PDB 2n8a chain A (observed residues)
PDB 2n8a chain A (observed residues)
PDB 2riq chain A (observed residues)
PDB 2riq chain A (observed residues)
PDB 7scy chain K (observed residues)
PDB 7scy chain K (observed residues)
PDB 2cr9 chain A (observed residues)
PDB 2cr9 chain A (observed residues)
PDB 4zzz chain A (observed residues)
PDB 4zzz chain A (observed residues)
PDB 4zzz chain A (observed residues)
PDB 4zzz chain A (observed residues)

PDB chain shown: 2n8a A go to PDBe

UniProt residues 1 - 214

Coverage: 21%

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100
Structures

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81
Ligands

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5
Interactions

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0
Similarity


571
Publications

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Processed Proteins (2):

Protein Name
Representative Structures
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Available Structural Data
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Poly [ADP-ribose] polymerase 1, processed N-terminus
UniProt range of the processed protein: 2 - 214
UniProt range of representative PDB 3oda chain C: 2 - 96
 15 Number of PDB structures
 1 Number of ligands
 2 Number of interaction partners
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Poly [ADP-ribose] polymerase 1, processed C-terminus
UniProt range of the processed protein: 215 - 1014
UniProt range of representative PDB 2riq chain A: 216 - 366
 90 Number of PDB structures
 123 Number of ligands
 5 Number of interaction partners
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