DNA topoisomerase 1

Gene:

TOP1 Enzyme: EC 5.6.2.1 This enzyme has known catalytic activity involved in reaction: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining. Disease 

Organism:

Homo sapiens (Human)

Uniprot:

P11387go to UniProt

Biological function:

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and ... [show more]go to UniProt

Representative structure for UniProt P11387

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PDB 1t8i chain D (observed residues)
PDB 1t8i chain D (observed residues)

PDB chain shown: 1t8i D go to PDBe

UniProt residues 174 - 765

Coverage: 74%

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18
Similarity

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250
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