Proliferating cell nuclear antigen

Gene:

PCNA Disease Ataxia-telangiectasia-like disorder 2: A neurodegenerative disorder due to defects in DNA excision repair. ATLD2 is characterized by developmental delay, ataxia, sensorineural hearing loss, short stature, cutaneous and ocular telangiectasia, and photosensitivity... [click for more]

Organism:

Homo sapiens (Human)

Uniprot:

P12004go to UniProt

Biological function:

Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (PubMed:35585232). Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be ... [show more]go to UniProt

Representative structure for UniProt P12004

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PDB 6vvo chain H (observed residues)
PDB 6vvo chain H (observed residues)

PDB chain shown: 6vvo H go to PDBe

UniProt residues 1 - 261

Coverage: 98%

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91
Structures

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20
Ligands

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34
Interactions

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30
Similarity

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382
Publications

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