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Sodium/potassium-transporting ATPase subunit alpha-3
ATP1A3 Enzyme: EC 7.2.2.13 This enzyme has known catalytic activity involved in reaction: K(+)(out) + Na(+)(in) + ATP + H2O = K(+)(in) + Na(+)(out) + ADP + phosphate + H(+) Disease Dystonia 12: An autosomal dominant dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures... [click for more]
Homo sapiens (Human)
P13637go to UniProt
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrientsgo to UniProt
Representative structure for UniProt P13637
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PDB chain shown: 8d3y A go to PDBe
UniProt residues 1 - 1013
Coverage: 97%