Hepatocyte nuclear factor 1-alpha

Gene:

Hnf1a

Organism:

Rattus norvegicus (Rat)

Synonyms:

Hnf-1, Hnf-1a, Tcf1

Uniprot:

P15257go to UniProt

Biological function:

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity)go to UniProt

Representative structure for UniProt P15257

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PDB 1lfb chain A (observed residues)
PDB 1lfb chain A (observed residues)

PDB chain shown: 1lfb A go to PDBe

UniProt residues 195 - 286

Coverage: 12%

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