Sodium channel protein type 5 subunit alpha

Gene:

Scn5a Enzyme: EC undefined This enzyme has known catalytic activity involved in reaction: Na(+)(in) = Na(+)(out)

Organism:

Rattus norvegicus (Rat)

Uniprot:

P15389go to UniProt

Biological function:

Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass ... [show more]go to UniProt

Representative structure for UniProt P15389

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PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)
PDB 7k18 chain A (observed residues)

PDB chain shown: 7k18 A go to PDBe

UniProt residues 1 - 1898

Coverage: 57%

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7
Structures

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11
Ligands

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1
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6
Similarity

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81
Publications

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